Genetic characterization of influenza A viruses (H5N1) isolated from 3rd wave of Thailand AI outbreaks

Three major outbreaks of avian influenza (AI) occurred in Thailand. During the third episode in October 2005, we have isolated H5N1 viruses from one human case and three poultry cases. The whole genomes of AI viruses from human, chickens and quail from the outbreaks were characterized. Sequence anal...

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Veröffentlicht in:	Virus research 2006-12, Vol.122 (1), p.194-199
Hauptverfasser:	Amonsin, Alongkorn, Chutinimitkul, Salin, Pariyothorn, Nuananong, Songserm, Thaweesak, Damrongwantanapokin, Sudarat, Puranaveja, Suphasawatt, Jam-on, Rungroj, Sae-Heng, Namdee, Payungporn, Sunchai, Theamboonlers, Apiradee, Chaisingh, Arunee, Tantilertcharoen, Rachod, Suradhat, Sanipa, Thanawongnuwech, Roongroje, Poovorawan, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Characterization Disease Outbreaks - veterinary Genome, Viral H5N1 Hemagglutinin Glycoproteins, Influenza Virus - genetics Humans Influenza A virus Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - isolation & purification Influenza in Birds - epidemiology Influenza in Birds - virology Influenza, Human - virology Molecular Sequence Data Mutation Phylogeny Poultry - virology Quail - virology Sequence Homology Thailand Thailand - epidemiology Tigers - virology
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Beschreibung
Zusammenfassung:	Three major outbreaks of avian influenza (AI) occurred in Thailand. During the third episode in October 2005, we have isolated H5N1 viruses from one human case and three poultry cases. The whole genomes of AI viruses from human, chickens and quail from the outbreaks were characterized. Sequence analysis of eight gene segments revealed that the 2005 H5N1 viruses isolated in October 2005 were closely related to those recovered from chicken, tiger(s) and human(s) in January and July 2004. In addition, the genetic changes of the AI isolates at the HA cleavage site have been observed.
ISSN:	0168-1702 1872-7492
DOI:	10.1016/j.virusres.2006.06.016