Microreactor Synthesis of β-Peptides

Microreactor Synthesis of β-Peptides

Taming the insoluble: The reaction parameters of a β‐peptide synthesis were optimized using only small amounts of reagents in a silicon microreactor (see picture). The use of unusually high temperatures (up to 120 °C) reduces the reaction times. The insertion of a fluorous benzyl protecting group en...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-10, Vol.45 (42), p.7000-7003
Hauptverfasser: Flögel, Oliver, Codée, Jeroen D. C., Seebach, Dieter, Seeberger, Peter H.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - chemistry
Chromatography, Liquid
fluorous tags
Mass Spectrometry
microreactors
Nanotechnology
Peptides - chemical synthesis
Silicon
Solutions
synthetic methods
β-peptides
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Zusammenfassung:Taming the insoluble: The reaction parameters of a β‐peptide synthesis were optimized using only small amounts of reagents in a silicon microreactor (see picture). The use of unusually high temperatures (up to 120 °C) reduces the reaction times. The insertion of a fluorous benzyl protecting group enhances the efficiency of the synthesis.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200602167