Compounds with DNA cleaving activity from Kadsura ananosma

Two DNA cleavage agents, meso-dihydroguaiaretic acid (1) and isobavachalcone (2) together with the known α-ylangene, β-sitosterol, daucosterol, pentacosane, hexacosanic acid and cerotic acid 1-monoglyceride were isolated from the stem barks of Kadsura ananosma Kerr for the first time. Compounds 1 an...

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Veröffentlicht in:	Pharmazie 2006-10, Vol.61 (10), p.891-892
Hauptverfasser:	Chen, Ye-Gao, Song, Xiao-Ping, Hai, Li-Na, Lv, Yu-Ping, Fang, A., Halaweish, F., Liao, Xin-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Chalcones - chemistry Chalcones - pharmacology DNA - chemistry DNA - drug effects DNA, Superhelical - chemistry DNA, Superhelical - drug effects Guaiacol - analogs & derivatives Guaiacol - chemistry Guaiacol - pharmacology HeLa Cells Humans Kadsura - chemistry Leukemia - drug therapy Leukemia - pathology Lignans - chemistry Lignans - pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry Nucleic Acid Conformation Plant Bark - chemistry Plant Stems - chemistry
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Zusammenfassung:	Two DNA cleavage agents, meso-dihydroguaiaretic acid (1) and isobavachalcone (2) together with the known α-ylangene, β-sitosterol, daucosterol, pentacosane, hexacosanic acid and cerotic acid 1-monoglyceride were isolated from the stem barks of Kadsura ananosma Kerr for the first time. Compounds 1 and 2 showed relaxation of supercoiled DNA to nicked DNA. 1 represented a new structural type of DNA cleavage agent, while 2 was reported to show DNA strand-scission activity for the first time. 1 also showed significant cytotoxic effect on Hela and Leukemia cells in vitro.
ISSN:	0031-7144