Thrombocytopenia as a surrogate for cirrhosis and a marker for the identification of patients at high‐risk for hepatocellular carcinoma

Thrombocytopenia as a surrogate for cirrhosis and a marker for the identification of patients at high‐risk for hepatocellular carcinoma

BACKGROUND. The objective of this study was to examine the usefulness of platelet counts in the diagnosis of cirrhosis and for identifying high‐risk individuals in a community‐based hepatocellular carcinoma (HCC) screening program. METHODS. Pilot Study 1 determined the correlation between platelet c...

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Veröffentlicht in:Cancer 2006-11, Vol.107 (9), p.2212-2222
Hauptverfasser: Lu, Sheng‐Nan, Wang, Jing‐Houng, Liu, Shiann‐Long, Hung, Chao‐Hung, Chen, Chien‐Hung, Tung, Hung‐Da, Chen, Tsung‐Ming, Huang, Wu‐Shiung, Lee, Chuan‐Mo, Chen, Chia‐Cheng, Changchien, Chi‐Sin
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Area Under Curve
Biological and medical sciences
Blood Platelets - pathology
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - epidemiology
cirrhosis
Community Health Services
community screening
Comorbidity
Female
Fibrosis - diagnosis
Fibrosis - epidemiology
Hematologic and hematopoietic diseases
Hepatitis B - diagnosis
Hepatitis B - epidemiology
hepatitis B virus
Hepatitis C - diagnosis
Hepatitis C - epidemiology
hepatitis C virus
hepatocellular carcinoma
Humans
Liver Cirrhosis - diagnosis
Liver Cirrhosis - epidemiology
Liver Neoplasms - diagnosis
Liver Neoplasms - epidemiology
Male
Mass Screening
Medical sciences
Middle Aged
Pilot Projects
platelet
Platelet diseases and coagulopathies
Predictive Value of Tests
Prevalence
Risk Factors
Sensitivity and Specificity
Survival Rate
Taiwan - epidemiology
Thrombocytopenia - diagnosis
Thrombocytopenia - epidemiology
Tumors
ultrasonography
α‐fetoprotein
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Beschreibung
Zusammenfassung:BACKGROUND. The objective of this study was to examine the usefulness of platelet counts in the diagnosis of cirrhosis and for identifying high‐risk individuals in a community‐based hepatocellular carcinoma (HCC) screening program. METHODS. Pilot Study 1 determined the correlation between platelet counts and pathologic hepatic fibrosis scores among individuals with chronic hepatitis B virus (HBV) infection (n = 122 patients) and hepatitis C virus (HCV) infection (n = 244 patients). Pilot Study 2 investigated proportions of individuals with thrombocytopenia (
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.22242