Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon

Among rural populations in Cameroon, HIV-1 prevalence is low and the genetic diversity broad. An unusual population-level genetic background may modulate this pattern of HIV infection. We examined HIV-1 prevalence, CCR5Delta32 and CCR5 promoter -2459 G genotype frequency among 1390 rural inhabitants...

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Veröffentlicht in:	AIDS (London) 2007-02, Vol.21 (4), p.527-528
Hauptverfasser:	TORIMIRO, Judith N, WOLFE, Nathan D, THOMAS, Alero, MARTIN, Maureen P, MPOUDI-NGOLE, Eitel, TAMOUFE, Ubald, BIRX, Deborah L, CARRINGTON, Mary, BURKE, Donald S, CARR, Jean K
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biological and medical sciences Cameroon - epidemiology Gene Frequency Genetic Predisposition to Disease HIV Infections - epidemiology HIV Infections - genetics HIV Seroprevalence HIV-1 Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical sciences Receptors, CCR5 - genetics Rural Health - statistics & numerical data Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	Among rural populations in Cameroon, HIV-1 prevalence is low and the genetic diversity broad. An unusual population-level genetic background may modulate this pattern of HIV infection. We examined HIV-1 prevalence, CCR5Delta32 and CCR5 promoter -2459 G genotype frequency among 1390 rural inhabitants. No individual was identified with the CCR5Delta32 allele, but homozygotes for the CCR5 promoter variant -2459G (27.5%) were relatively common. A seroprevalence of 3.1% of HIV-1 was reported.
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0b013e328045c4bd