Conformational Control of Transmembrane Cl- Transport

Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Chemical Society 2007-02, Vol.129 (7), p.1886-1887
Hauptverfasser: Santacroce, Paul V, Davis, Jeffery T, Light, Mark E, Gale, Philip A, Iglesias-Sánchez, José Carlos, Prados, Pilar, Quesada, Roberto
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1887
container_issue 7
container_start_page 1886
container_title Journal of the American Chemical Society
container_volume 129
creator Santacroce, Paul V
Davis, Jeffery T
Light, Mark E
Gale, Philip A
Iglesias-Sánchez, José Carlos
Prados, Pilar
Quesada, Roberto
description Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the pH.
doi_str_mv 10.1021/ja068067v
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69004816</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69004816</sourcerecordid><originalsourceid>FETCH-LOGICAL-a417t-3885afe610fb3e4ddda42fa60869663ae626bff6c109687390baeff4218193433</originalsourceid><addsrcrecordid>eNptkEFLw0AQhRdRbK0e_APSi4KH6M5uMtkcJVgVCgqtIL0sm2QXUpNu3U1E_70rKfXiaXgzH29mHiHnQG-AMrhdK4qCYvp5QMaQMBolwPCQjCmlLEoF8hE58X4dZMwEHJMRpCzhmMGYJLndGOta1dV2o5ppkJ2zzdSa6dKpjW91W4Sqp3kTDZ2tdd0pOTKq8fpsVyfkdXa_zB-j-fPDU343j1QMaRdxIRJlNAI1BddxVVUqZkYhFZghcqWRYWEMlkAzFCnPaKG0MTEDARmPOZ-Qq8F36-xHr30n29qXumnCRbb3ErPwkgAM4PUAls5677SRW1e3yn1LoPI3I7nPKLAXO9O-aHX1R-5CCUA0ALXv9Nd-rty7xJSniVy-LCSuZm8rmgu5CPzlwKvSy7XtXQjS_7P4B5CAe5M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69004816</pqid></control><display><type>article</type><title>Conformational Control of Transmembrane Cl- Transport</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Santacroce, Paul V ; Davis, Jeffery T ; Light, Mark E ; Gale, Philip A ; Iglesias-Sánchez, José Carlos ; Prados, Pilar ; Quesada, Roberto</creator><creatorcontrib>Santacroce, Paul V ; Davis, Jeffery T ; Light, Mark E ; Gale, Philip A ; Iglesias-Sánchez, José Carlos ; Prados, Pilar ; Quesada, Roberto</creatorcontrib><description>Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the pH.</description><identifier>ISSN: 0002-7863</identifier><identifier>EISSN: 1520-5126</identifier><identifier>DOI: 10.1021/ja068067v</identifier><identifier>PMID: 17253691</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Amides - chemistry ; Amides - metabolism ; Chlorides - chemistry ; Chlorides - metabolism ; Crystallography, X-Ray ; Hydrogen Bonding ; Ion Transport ; Lipid Bilayers - chemistry ; Lipid Bilayers - metabolism ; Liposomes - chemistry ; Models, Molecular ; Molecular Conformation ; Organic Anion Transporters - chemistry ; Organic Anion Transporters - metabolism ; Phthalic Acids - chemistry ; Phthalic Acids - metabolism</subject><ispartof>Journal of the American Chemical Society, 2007-02, Vol.129 (7), p.1886-1887</ispartof><rights>Copyright © 2007 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a417t-3885afe610fb3e4ddda42fa60869663ae626bff6c109687390baeff4218193433</citedby><cites>FETCH-LOGICAL-a417t-3885afe610fb3e4ddda42fa60869663ae626bff6c109687390baeff4218193433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ja068067v$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ja068067v$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17253691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santacroce, Paul V</creatorcontrib><creatorcontrib>Davis, Jeffery T</creatorcontrib><creatorcontrib>Light, Mark E</creatorcontrib><creatorcontrib>Gale, Philip A</creatorcontrib><creatorcontrib>Iglesias-Sánchez, José Carlos</creatorcontrib><creatorcontrib>Prados, Pilar</creatorcontrib><creatorcontrib>Quesada, Roberto</creatorcontrib><title>Conformational Control of Transmembrane Cl- Transport</title><title>Journal of the American Chemical Society</title><addtitle>J. Am. Chem. Soc</addtitle><description>Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the pH.</description><subject>Amides - chemistry</subject><subject>Amides - metabolism</subject><subject>Chlorides - chemistry</subject><subject>Chlorides - metabolism</subject><subject>Crystallography, X-Ray</subject><subject>Hydrogen Bonding</subject><subject>Ion Transport</subject><subject>Lipid Bilayers - chemistry</subject><subject>Lipid Bilayers - metabolism</subject><subject>Liposomes - chemistry</subject><subject>Models, Molecular</subject><subject>Molecular Conformation</subject><subject>Organic Anion Transporters - chemistry</subject><subject>Organic Anion Transporters - metabolism</subject><subject>Phthalic Acids - chemistry</subject><subject>Phthalic Acids - metabolism</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFLw0AQhRdRbK0e_APSi4KH6M5uMtkcJVgVCgqtIL0sm2QXUpNu3U1E_70rKfXiaXgzH29mHiHnQG-AMrhdK4qCYvp5QMaQMBolwPCQjCmlLEoF8hE58X4dZMwEHJMRpCzhmMGYJLndGOta1dV2o5ppkJ2zzdSa6dKpjW91W4Sqp3kTDZ2tdd0pOTKq8fpsVyfkdXa_zB-j-fPDU343j1QMaRdxIRJlNAI1BddxVVUqZkYhFZghcqWRYWEMlkAzFCnPaKG0MTEDARmPOZ-Qq8F36-xHr30n29qXumnCRbb3ErPwkgAM4PUAls5677SRW1e3yn1LoPI3I7nPKLAXO9O-aHX1R-5CCUA0ALXv9Nd-rty7xJSniVy-LCSuZm8rmgu5CPzlwKvSy7XtXQjS_7P4B5CAe5M</recordid><startdate>20070221</startdate><enddate>20070221</enddate><creator>Santacroce, Paul V</creator><creator>Davis, Jeffery T</creator><creator>Light, Mark E</creator><creator>Gale, Philip A</creator><creator>Iglesias-Sánchez, José Carlos</creator><creator>Prados, Pilar</creator><creator>Quesada, Roberto</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070221</creationdate><title>Conformational Control of Transmembrane Cl- Transport</title><author>Santacroce, Paul V ; Davis, Jeffery T ; Light, Mark E ; Gale, Philip A ; Iglesias-Sánchez, José Carlos ; Prados, Pilar ; Quesada, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a417t-3885afe610fb3e4ddda42fa60869663ae626bff6c109687390baeff4218193433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Amides - chemistry</topic><topic>Amides - metabolism</topic><topic>Chlorides - chemistry</topic><topic>Chlorides - metabolism</topic><topic>Crystallography, X-Ray</topic><topic>Hydrogen Bonding</topic><topic>Ion Transport</topic><topic>Lipid Bilayers - chemistry</topic><topic>Lipid Bilayers - metabolism</topic><topic>Liposomes - chemistry</topic><topic>Models, Molecular</topic><topic>Molecular Conformation</topic><topic>Organic Anion Transporters - chemistry</topic><topic>Organic Anion Transporters - metabolism</topic><topic>Phthalic Acids - chemistry</topic><topic>Phthalic Acids - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santacroce, Paul V</creatorcontrib><creatorcontrib>Davis, Jeffery T</creatorcontrib><creatorcontrib>Light, Mark E</creatorcontrib><creatorcontrib>Gale, Philip A</creatorcontrib><creatorcontrib>Iglesias-Sánchez, José Carlos</creatorcontrib><creatorcontrib>Prados, Pilar</creatorcontrib><creatorcontrib>Quesada, Roberto</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santacroce, Paul V</au><au>Davis, Jeffery T</au><au>Light, Mark E</au><au>Gale, Philip A</au><au>Iglesias-Sánchez, José Carlos</au><au>Prados, Pilar</au><au>Quesada, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conformational Control of Transmembrane Cl- Transport</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2007-02-21</date><risdate>2007</risdate><volume>129</volume><issue>7</issue><spage>1886</spage><epage>1887</epage><pages>1886-1887</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the pH.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>17253691</pmid><doi>10.1021/ja068067v</doi><tpages>2</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0002-7863
ispartof Journal of the American Chemical Society, 2007-02, Vol.129 (7), p.1886-1887
issn 0002-7863
1520-5126
language eng
recordid cdi_proquest_miscellaneous_69004816
source MEDLINE; American Chemical Society Journals
subjects Amides - chemistry
Amides - metabolism
Chlorides - chemistry
Chlorides - metabolism
Crystallography, X-Ray
Hydrogen Bonding
Ion Transport
Lipid Bilayers - chemistry
Lipid Bilayers - metabolism
Liposomes - chemistry
Models, Molecular
Molecular Conformation
Organic Anion Transporters - chemistry
Organic Anion Transporters - metabolism
Phthalic Acids - chemistry
Phthalic Acids - metabolism
title Conformational Control of Transmembrane Cl- Transport
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T22%3A36%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Conformational%20Control%20of%20Transmembrane%20Cl-%20Transport&rft.jtitle=Journal%20of%20the%20American%20Chemical%20Society&rft.au=Santacroce,%20Paul%20V&rft.date=2007-02-21&rft.volume=129&rft.issue=7&rft.spage=1886&rft.epage=1887&rft.pages=1886-1887&rft.issn=0002-7863&rft.eissn=1520-5126&rft_id=info:doi/10.1021/ja068067v&rft_dat=%3Cproquest_cross%3E69004816%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69004816&rft_id=info:pmid/17253691&rfr_iscdi=true