Conformational Control of Transmembrane Cl- Transport

Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the...

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Veröffentlicht in:	Journal of the American Chemical Society 2007-02, Vol.129 (7), p.1886-1887
Hauptverfasser:	Santacroce, Paul V, Davis, Jeffery T, Light, Mark E, Gale, Philip A, Iglesias-Sánchez, José Carlos, Prados, Pilar, Quesada, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - metabolism Chlorides - chemistry Chlorides - metabolism Crystallography, X-Ray Hydrogen Bonding Ion Transport Lipid Bilayers - chemistry Lipid Bilayers - metabolism Liposomes - chemistry Models, Molecular Molecular Conformation Organic Anion Transporters - chemistry Organic Anion Transporters - metabolism Phthalic Acids - chemistry Phthalic Acids - metabolism
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Beschreibung
Zusammenfassung:	Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the pH.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja068067v