Integerrimides A and B, Cyclic Heptapeptides from the Latex of Jatropha integerrima

Two new cyclic heptapeptides, integerrimides A and B, have been isolated from the latex of Jatropha integerrima. Their structures were elucidated by using extensive 1D and 2D NMR, MS, and chemical degradation. At 50 μM both peptides 1 and 2 significantly inhibited neurite outgrowth in neuronal cell...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-10, Vol.69 (10), p.1435-1441
Hauptverfasser:	Mongkolvisut, Wantana, Sutthivaiyakit, Somyote, Leutbecher, Heiko, Mika, Sabine, Klaiber, Iris, Möller, Wolfgang, Rösner, Harald, Beifuss, Uwe, Conrad, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Candida albicans - drug effects Chickens Drug Screening Assays, Antitumor General pharmacology Herpesvirus 1, Human - drug effects Humans Jatropha - chemistry Latex - chemistry Medical sciences Molecular Structure Neurites - drug effects Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Plasmodium falciparum - drug effects Spinal Cord - cytology Spinal Cord - drug effects Thailand
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Zusammenfassung:	Two new cyclic heptapeptides, integerrimides A and B, have been isolated from the latex of Jatropha integerrima. Their structures were elucidated by using extensive 1D and 2D NMR, MS, and chemical degradation. At 50 μM both peptides 1 and 2 significantly inhibited neurite outgrowth in neuronal cell culture. They also partially inhibited proliferation of human IPC-298 melanoma cells as well as migration of human Capan II pancreatic carcinoma cells, but were inactive in HSV-1, antifungal, and antimalarial assays.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0602012