Clinical experience with U-500 regular insulin in obese, markedly insulin-resistant type 2 diabetic patients

In adults, the conditions associated with clinical insulin resistance are gross obesity, severe infection, Cushing's syndrome, acromegaly, hemochromatosis, lipodystrophic diabetes, genetic insulin receptor abnormalities, insulin receptor antibodies, Werner's syndrome (adult form of progeria), insulin degradation at the injection site, and high tilers of IgG insulin binding antibodies (immune mediated).