Meta-Analysis of Fractional Flow Reserve Versus Quantitative Coronary Angiography and Noninvasive Imaging for Evaluation of Myocardial Ischemia

We performed a meta-analysis of 31 studies comparing the results of fractional flow reserve (FFR) against quantitative coronary angiography (QCA) and/or noninvasive imaging of the same lesions. Studies were retrieved from PubMed (last search February 2006). Across 18 studies (1,522 lesions), QCA had...

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Veröffentlicht in:	The American journal of cardiology 2007-02, Vol.99 (4), p.450-456
Hauptverfasser:	Christou, Maria A.C, Siontis, George C.M, Katritsis, Demosthenes G., MD, PhD, Ioannidis, John P.A., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Flow Velocity Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cardiovascular system Coronary Angiography - methods Coronary Circulation Coronary heart disease Diagnostic Imaging Heart Humans Investigative techniques, diagnostic techniques (general aspects) Medical imaging Medical sciences Meta-analysis Myocardial Ischemia - diagnostic imaging Myocarditis. Cardiomyopathies Radiodiagnosis. Nmr imagery. Nmr spectrometry ROC Curve Sensitivity and Specificity
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Zusammenfassung:	We performed a meta-analysis of 31 studies comparing the results of fractional flow reserve (FFR) against quantitative coronary angiography (QCA) and/or noninvasive imaging of the same lesions. Studies were retrieved from PubMed (last search February 2006). Across 18 studies (1,522 lesions), QCA had a random effects sensitivity of 78% (95% confidence interval [CI] 67 to 86) and specificity of 51% (95% CI 40 to 61) against FFR (0.75 cutoff). Overall concordances were 61% for lesions with diameter stenosis 30% to 70%, 67% for stenoses >70%, and 95% for stenoses
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2006.09.092