Combination Treatment With Donor Interleukin-12p35 Silenced Dendritic Cells and Cyclosporine Induces Long-Term Survival of Intestinal Allografts in Rats

Abstract Immune tolerance promises to enhance allograft survival while reducing risks inherent to immunosuppressants. In this study, we evaluated the effect of interleukin (IL)-12p35 silenced dendritic cells (DC) combined with cyclosporine (CsA) on induction of immune tolerance in intestinal transpl...

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Veröffentlicht in:	Transplantation proceedings 2007, Vol.39 (1), p.286-288
Hauptverfasser:	Xu, H, Chen, T, Wang, H.Q, Hua, Y.B, Wu, W.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Combined Modality Therapy Cyclosporine - therapeutic use Dendritic Cells - immunology Dendritic Cells - transplantation Gene Silencing Graft Survival - immunology Interleukin-12 Subunit p35 - genetics Intestine, Small - transplantation Intestines - transplantation Male Models, Animal Rats Rats, Inbred WF Rats, Sprague-Dawley Surgery Survival Transplantation, Homologous - immunology
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Zusammenfassung:	Abstract Immune tolerance promises to enhance allograft survival while reducing risks inherent to immunosuppressants. In this study, we evaluated the effect of interleukin (IL)-12p35 silenced dendritic cells (DC) combined with cyclosporine (CsA) on induction of immune tolerance in intestinal transplantation. The results showed that combination treatment with donor IL-12p35 silenced DC and a low dose of CsA (8 mg/kg) prolonged rat intestinal allograft survival. However, a higher dose of CsA (20 mg/kg) did not further prolong allograft survival.
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2006.10.229