Postchallenge glucose rises with increasing age even when glucose tolerance is normal
Aims Ageing increases the likelihood of developing diabetes, with associated cardiovascular disease. In a cross‐sectional study, we sought to determine whether age is associated with an increase in glucose concentrations 1 h after an oral glucose challenge (1‐h OGTT), even when glucose tolerance is...
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| Veröffentlicht in: | Diabetic medicine 2006-11, Vol.23 (11), p.1174-1179 |
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| container_title | Diabetic medicine |
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| creator | Rhee, M. K. Ziemer, D. C. Kolm, P. Phillips, L. S. |
| description | Aims Ageing increases the likelihood of developing diabetes, with associated cardiovascular disease. In a cross‐sectional study, we sought to determine whether age is associated with an increase in glucose concentrations 1 h after an oral glucose challenge (1‐h OGTT), even when glucose tolerance is normal (NGT).
Methods Among subjects in the NHANES II database, 2591 subjects with NGT and documented 1‐h OGTT glucose concentrations were studied. The relationship between age and 1‐h OGTT glucose concentrations was assessed in a multivariable linear regression analysis.
Results In a multivariable linear regression analysis, each 10‐year increase in age conferred an additional 0.20 mmol/l increase in the 1‐h OGTT glucose (P |
| doi_str_mv | 10.1111/j.1464-5491.2006.01956.x |
| format | Article |
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Methods Among subjects in the NHANES II database, 2591 subjects with NGT and documented 1‐h OGTT glucose concentrations were studied. The relationship between age and 1‐h OGTT glucose concentrations was assessed in a multivariable linear regression analysis.
Results In a multivariable linear regression analysis, each 10‐year increase in age conferred an additional 0.20 mmol/l increase in the 1‐h OGTT glucose (P < 0.0001). Moreover, an interaction between age and gender was found such that 1‐h OGTT glucose concentrations rose more rapidly with increasing age in men than in women. The impact of age on 1‐h OGTT glucose was independent of both fasting and 2‐h OGTT glucose concentrations.
Conclusions One‐hour OGTT glucose concentrations rise significantly with age even in subjects with NGT. Further investigation is warranted to explore the pathophysiological significance of such age‐related impairment of glucose handling, which might increase the risk of cardiovascular disease even when patients do not meet criteria for the diagnosis of diabetes or prediabetes.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2006.01956.x</identifier><identifier>PMID: 17054591</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; ageing ; Biological and medical sciences ; Blood Glucose - metabolism ; Child ; Child, Preschool ; Cross-Sectional Studies ; Diabetes Mellitus - blood ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; glucose intolerance ; Glucose Intolerance - metabolism ; Humans ; Infant ; Male ; Medical sciences ; Middle Aged ; postchallenge glucose ; Risk Factors ; Time Factors</subject><ispartof>Diabetic medicine, 2006-11, Vol.23 (11), p.1174-1179</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4356-bc4b4f5e252021757b25b07e0ab1592cbda24904872924718d5e40b47a092c5e3</citedby><cites>FETCH-LOGICAL-c4356-bc4b4f5e252021757b25b07e0ab1592cbda24904872924718d5e40b47a092c5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-5491.2006.01956.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-5491.2006.01956.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18203891$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17054591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rhee, M. K.</creatorcontrib><creatorcontrib>Ziemer, D. C.</creatorcontrib><creatorcontrib>Kolm, P.</creatorcontrib><creatorcontrib>Phillips, L. S.</creatorcontrib><title>Postchallenge glucose rises with increasing age even when glucose tolerance is normal</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims Ageing increases the likelihood of developing diabetes, with associated cardiovascular disease. In a cross‐sectional study, we sought to determine whether age is associated with an increase in glucose concentrations 1 h after an oral glucose challenge (1‐h OGTT), even when glucose tolerance is normal (NGT).
Methods Among subjects in the NHANES II database, 2591 subjects with NGT and documented 1‐h OGTT glucose concentrations were studied. The relationship between age and 1‐h OGTT glucose concentrations was assessed in a multivariable linear regression analysis.
Results In a multivariable linear regression analysis, each 10‐year increase in age conferred an additional 0.20 mmol/l increase in the 1‐h OGTT glucose (P < 0.0001). Moreover, an interaction between age and gender was found such that 1‐h OGTT glucose concentrations rose more rapidly with increasing age in men than in women. The impact of age on 1‐h OGTT glucose was independent of both fasting and 2‐h OGTT glucose concentrations.
Conclusions One‐hour OGTT glucose concentrations rise significantly with age even in subjects with NGT. Further investigation is warranted to explore the pathophysiological significance of such age‐related impairment of glucose handling, which might increase the risk of cardiovascular disease even when patients do not meet criteria for the diagnosis of diabetes or prediabetes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>ageing</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>glucose intolerance</subject><subject>Glucose Intolerance - metabolism</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>postchallenge glucose</subject><subject>Risk Factors</subject><subject>Time Factors</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vEzEQhi0EoqHwF5AvcNvFn-v1gQNKS1sIH0JUPVpeZ5I4OLvFsyHpv2e3Ce2VOXgszfOOrYcQylnJh3q3LrmqVKGV5aVgrCoZt7oq90_I5GHwlEyYUaKQzPAT8gJxzRgXVtrn5IQbppW2fEKuv3fYh5VPCdol0GXahg6B5oiAdBf7FY1tyOAxtkvqBwL-QEt3q-H4x_ZdguzbADQibbu88eklebbwCeHVsZ-S64_nP6eXxezbxdX0w6wISuqqaIJq1EKD0IIJbrRphG6YAeYbrq0IzdwLZZmqjbBCGV7PNSjWKOPZMNUgT8nbw97b3P3eAvZuEzFASr6Fbouuqm2tpNQDWB_AkDvEDAt3m-PG5zvHmRuVurUbzbnRnBuVunulbj9EXx_f2DYbmD8Gjw4H4M0R8Bh8WowuIj5ytWCyvufeH7hdTHD33x9wZ1_Ox9uQLw75iD3sH_I-_3KVkUa7m68X7of8_EnNppW7kX8BTQ2ghw</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Rhee, M. K.</creator><creator>Ziemer, D. C.</creator><creator>Kolm, P.</creator><creator>Phillips, L. S.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Postchallenge glucose rises with increasing age even when glucose tolerance is normal</title><author>Rhee, M. K. ; Ziemer, D. C. ; Kolm, P. ; Phillips, L. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4356-bc4b4f5e252021757b25b07e0ab1592cbda24904872924718d5e40b47a092c5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>ageing</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - diagnosis</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>glucose intolerance</topic><topic>Glucose Intolerance - metabolism</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>postchallenge glucose</topic><topic>Risk Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rhee, M. K.</creatorcontrib><creatorcontrib>Ziemer, D. C.</creatorcontrib><creatorcontrib>Kolm, P.</creatorcontrib><creatorcontrib>Phillips, L. S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rhee, M. K.</au><au>Ziemer, D. C.</au><au>Kolm, P.</au><au>Phillips, L. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postchallenge glucose rises with increasing age even when glucose tolerance is normal</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2006-11</date><risdate>2006</risdate><volume>23</volume><issue>11</issue><spage>1174</spage><epage>1179</epage><pages>1174-1179</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims Ageing increases the likelihood of developing diabetes, with associated cardiovascular disease. In a cross‐sectional study, we sought to determine whether age is associated with an increase in glucose concentrations 1 h after an oral glucose challenge (1‐h OGTT), even when glucose tolerance is normal (NGT).
Methods Among subjects in the NHANES II database, 2591 subjects with NGT and documented 1‐h OGTT glucose concentrations were studied. The relationship between age and 1‐h OGTT glucose concentrations was assessed in a multivariable linear regression analysis.
Results In a multivariable linear regression analysis, each 10‐year increase in age conferred an additional 0.20 mmol/l increase in the 1‐h OGTT glucose (P < 0.0001). Moreover, an interaction between age and gender was found such that 1‐h OGTT glucose concentrations rose more rapidly with increasing age in men than in women. The impact of age on 1‐h OGTT glucose was independent of both fasting and 2‐h OGTT glucose concentrations.
Conclusions One‐hour OGTT glucose concentrations rise significantly with age even in subjects with NGT. Further investigation is warranted to explore the pathophysiological significance of such age‐related impairment of glucose handling, which might increase the risk of cardiovascular disease even when patients do not meet criteria for the diagnosis of diabetes or prediabetes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17054591</pmid><doi>10.1111/j.1464-5491.2006.01956.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged ageing Biological and medical sciences Blood Glucose - metabolism Child Child, Preschool Cross-Sectional Studies Diabetes Mellitus - blood Diabetes Mellitus - diagnosis Diabetes Mellitus - epidemiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female glucose intolerance Glucose Intolerance - metabolism Humans Infant Male Medical sciences Middle Aged postchallenge glucose Risk Factors Time Factors |
| title | Postchallenge glucose rises with increasing age even when glucose tolerance is normal |
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