Postchallenge glucose rises with increasing age even when glucose tolerance is normal

Aims Ageing increases the likelihood of developing diabetes, with associated cardiovascular disease. In a cross‐sectional study, we sought to determine whether age is associated with an increase in glucose concentrations 1 h after an oral glucose challenge (1‐h OGTT), even when glucose tolerance is normal (NGT). Methods Among subjects in the NHANES II database, 2591 subjects with NGT and documented 1‐h OGTT glucose concentrations were studied. The relationship between age and 1‐h OGTT glucose concentrations was assessed in a multivariable linear regression analysis. Results In a multivariable linear regression analysis, each 10‐year increase in age conferred an additional 0.20 mmol/l increase in the 1‐h OGTT glucose (P