Longitudinal changes in white matter following ischemic stroke: A three-year follow-up study
Information on longitudinal changes in white matter after stroke is limited. The aim of the present study was to quantitatively investigate longitudinal changes in the microstructural integrity of non-lesioned white matter at 1–3 years following ischemic stroke. In a sample of 80 ischemic stroke pat...
Gespeichert in:
| Veröffentlicht in: | Neurobiology of aging 2006-12, Vol.27 (12), p.1827-1833 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1833 |
|---|---|
| container_issue | 12 |
| container_start_page | 1827 |
| container_title | Neurobiology of aging |
| container_volume | 27 |
| creator | Wang, Changsheng Stebbins, Glenn T. Nyenhuis, David L. deToledo-Morrell, Leyla Freels, Sally Gencheva, Eugenia Pedelty, Laura Sripathirathan, Kumar Moseley, Michael E. Turner, David A. Gabrieli, John D.E. Gorelick, Philip B. |
| description | Information on longitudinal changes in white matter after stroke is limited. The aim of the present study was to quantitatively investigate longitudinal changes in the microstructural integrity of non-lesioned white matter at 1–3 years following ischemic stroke. In a sample of 80 ischemic stroke patients, we obtained diffusion tensor imaging (DTI) measures of fractional anisotropy (FA), an apparent measure of white matter integrity, in radiologically normal-appearing white matter at baseline and 3 years of follow-up. Mixed model regression analysis results showed a significant improvement in FA from baseline during the first 2 years of follow-up that stabilized by the third year of follow-up. These results demonstrate a long-term improvement in apparent white matter integrity following ischemic stroke that continues, at least, into the second year following the insult. |
| doi_str_mv | 10.1016/j.neurobiolaging.2005.10.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68984262</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0197458005003386</els_id><sourcerecordid>68984262</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-aeb1c7ef3933b7ffd7865fe61bef29217a5e65503abaecc7cd07e1bda0af3a8f3</originalsourceid><addsrcrecordid>eNqNkE1LAzEURYMotn78BclC3E1N5isZcSNiVSi40Z0QMpmXNnVmUpOMpf_elFbEnau3uOflvhyELimZUELL6-Wkh8HZ2thWzk0_n6SEFDGaEMIP0JgWBU9oXrFDNCa0YklecDJCJ94vCSEsZ-UxGtEyo4RX6Ri9z2w_N2FoTC9brBayn4PHpsfrhQmAOxkCOKxt29p1LMPGqwV0RmEfnP2AG3yHw8IBJBuQP1wyrGI8NJszdKRl6-F8P0_R2_Th9f4pmb08Pt_fzRKV8TwkEmqqGOisyrKaad0wXhYaSlqDTquUMllAWRQkk7UEpZhqCANaN5JInUmus1N0tXt35eznAD6ILt4JbSt7sIMXJa94npZpBG93oHLWewdarJzppNsISsTWrliKv3bF1u42jXbj-sW-Z6g7aH6X9zojMN0BEH_7ZcAJrwz0ChrjQAXRWPO_pm-UG5dP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68984262</pqid></control><display><type>article</type><title>Longitudinal changes in white matter following ischemic stroke: A three-year follow-up study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Wang, Changsheng ; Stebbins, Glenn T. ; Nyenhuis, David L. ; deToledo-Morrell, Leyla ; Freels, Sally ; Gencheva, Eugenia ; Pedelty, Laura ; Sripathirathan, Kumar ; Moseley, Michael E. ; Turner, David A. ; Gabrieli, John D.E. ; Gorelick, Philip B.</creator><creatorcontrib>Wang, Changsheng ; Stebbins, Glenn T. ; Nyenhuis, David L. ; deToledo-Morrell, Leyla ; Freels, Sally ; Gencheva, Eugenia ; Pedelty, Laura ; Sripathirathan, Kumar ; Moseley, Michael E. ; Turner, David A. ; Gabrieli, John D.E. ; Gorelick, Philip B.</creatorcontrib><description>Information on longitudinal changes in white matter after stroke is limited. The aim of the present study was to quantitatively investigate longitudinal changes in the microstructural integrity of non-lesioned white matter at 1–3 years following ischemic stroke. In a sample of 80 ischemic stroke patients, we obtained diffusion tensor imaging (DTI) measures of fractional anisotropy (FA), an apparent measure of white matter integrity, in radiologically normal-appearing white matter at baseline and 3 years of follow-up. Mixed model regression analysis results showed a significant improvement in FA from baseline during the first 2 years of follow-up that stabilized by the third year of follow-up. These results demonstrate a long-term improvement in apparent white matter integrity following ischemic stroke that continues, at least, into the second year following the insult.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2005.10.008</identifier><identifier>PMID: 16310892</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Brain Ischemia - epidemiology ; Brain Ischemia - pathology ; Cerebral ischemia ; Diffusion Magnetic Resonance Imaging - methods ; DTI ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Longitudinal survey ; Male ; Middle Aged ; MRI ; Nerve Fibers, Myelinated - pathology ; Prospective Studies ; Time Factors</subject><ispartof>Neurobiology of aging, 2006-12, Vol.27 (12), p.1827-1833</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-aeb1c7ef3933b7ffd7865fe61bef29217a5e65503abaecc7cd07e1bda0af3a8f3</citedby><cites>FETCH-LOGICAL-c384t-aeb1c7ef3933b7ffd7865fe61bef29217a5e65503abaecc7cd07e1bda0af3a8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2005.10.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16310892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Changsheng</creatorcontrib><creatorcontrib>Stebbins, Glenn T.</creatorcontrib><creatorcontrib>Nyenhuis, David L.</creatorcontrib><creatorcontrib>deToledo-Morrell, Leyla</creatorcontrib><creatorcontrib>Freels, Sally</creatorcontrib><creatorcontrib>Gencheva, Eugenia</creatorcontrib><creatorcontrib>Pedelty, Laura</creatorcontrib><creatorcontrib>Sripathirathan, Kumar</creatorcontrib><creatorcontrib>Moseley, Michael E.</creatorcontrib><creatorcontrib>Turner, David A.</creatorcontrib><creatorcontrib>Gabrieli, John D.E.</creatorcontrib><creatorcontrib>Gorelick, Philip B.</creatorcontrib><title>Longitudinal changes in white matter following ischemic stroke: A three-year follow-up study</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Information on longitudinal changes in white matter after stroke is limited. The aim of the present study was to quantitatively investigate longitudinal changes in the microstructural integrity of non-lesioned white matter at 1–3 years following ischemic stroke. In a sample of 80 ischemic stroke patients, we obtained diffusion tensor imaging (DTI) measures of fractional anisotropy (FA), an apparent measure of white matter integrity, in radiologically normal-appearing white matter at baseline and 3 years of follow-up. Mixed model regression analysis results showed a significant improvement in FA from baseline during the first 2 years of follow-up that stabilized by the third year of follow-up. These results demonstrate a long-term improvement in apparent white matter integrity following ischemic stroke that continues, at least, into the second year following the insult.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain Ischemia - epidemiology</subject><subject>Brain Ischemia - pathology</subject><subject>Cerebral ischemia</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>DTI</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Longitudinal survey</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>Prospective Studies</subject><subject>Time Factors</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LAzEURYMotn78BclC3E1N5isZcSNiVSi40Z0QMpmXNnVmUpOMpf_elFbEnau3uOflvhyELimZUELL6-Wkh8HZ2thWzk0_n6SEFDGaEMIP0JgWBU9oXrFDNCa0YklecDJCJ94vCSEsZ-UxGtEyo4RX6Ri9z2w_N2FoTC9brBayn4PHpsfrhQmAOxkCOKxt29p1LMPGqwV0RmEfnP2AG3yHw8IBJBuQP1wyrGI8NJszdKRl6-F8P0_R2_Th9f4pmb08Pt_fzRKV8TwkEmqqGOisyrKaad0wXhYaSlqDTquUMllAWRQkk7UEpZhqCANaN5JInUmus1N0tXt35eznAD6ILt4JbSt7sIMXJa94npZpBG93oHLWewdarJzppNsISsTWrliKv3bF1u42jXbj-sW-Z6g7aH6X9zojMN0BEH_7ZcAJrwz0ChrjQAXRWPO_pm-UG5dP</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Wang, Changsheng</creator><creator>Stebbins, Glenn T.</creator><creator>Nyenhuis, David L.</creator><creator>deToledo-Morrell, Leyla</creator><creator>Freels, Sally</creator><creator>Gencheva, Eugenia</creator><creator>Pedelty, Laura</creator><creator>Sripathirathan, Kumar</creator><creator>Moseley, Michael E.</creator><creator>Turner, David A.</creator><creator>Gabrieli, John D.E.</creator><creator>Gorelick, Philip B.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Longitudinal changes in white matter following ischemic stroke: A three-year follow-up study</title><author>Wang, Changsheng ; Stebbins, Glenn T. ; Nyenhuis, David L. ; deToledo-Morrell, Leyla ; Freels, Sally ; Gencheva, Eugenia ; Pedelty, Laura ; Sripathirathan, Kumar ; Moseley, Michael E. ; Turner, David A. ; Gabrieli, John D.E. ; Gorelick, Philip B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-aeb1c7ef3933b7ffd7865fe61bef29217a5e65503abaecc7cd07e1bda0af3a8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain Ischemia - epidemiology</topic><topic>Brain Ischemia - pathology</topic><topic>Cerebral ischemia</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>DTI</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Longitudinal survey</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Nerve Fibers, Myelinated - pathology</topic><topic>Prospective Studies</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Changsheng</creatorcontrib><creatorcontrib>Stebbins, Glenn T.</creatorcontrib><creatorcontrib>Nyenhuis, David L.</creatorcontrib><creatorcontrib>deToledo-Morrell, Leyla</creatorcontrib><creatorcontrib>Freels, Sally</creatorcontrib><creatorcontrib>Gencheva, Eugenia</creatorcontrib><creatorcontrib>Pedelty, Laura</creatorcontrib><creatorcontrib>Sripathirathan, Kumar</creatorcontrib><creatorcontrib>Moseley, Michael E.</creatorcontrib><creatorcontrib>Turner, David A.</creatorcontrib><creatorcontrib>Gabrieli, John D.E.</creatorcontrib><creatorcontrib>Gorelick, Philip B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Changsheng</au><au>Stebbins, Glenn T.</au><au>Nyenhuis, David L.</au><au>deToledo-Morrell, Leyla</au><au>Freels, Sally</au><au>Gencheva, Eugenia</au><au>Pedelty, Laura</au><au>Sripathirathan, Kumar</au><au>Moseley, Michael E.</au><au>Turner, David A.</au><au>Gabrieli, John D.E.</au><au>Gorelick, Philip B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal changes in white matter following ischemic stroke: A three-year follow-up study</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>27</volume><issue>12</issue><spage>1827</spage><epage>1833</epage><pages>1827-1833</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Information on longitudinal changes in white matter after stroke is limited. The aim of the present study was to quantitatively investigate longitudinal changes in the microstructural integrity of non-lesioned white matter at 1–3 years following ischemic stroke. In a sample of 80 ischemic stroke patients, we obtained diffusion tensor imaging (DTI) measures of fractional anisotropy (FA), an apparent measure of white matter integrity, in radiologically normal-appearing white matter at baseline and 3 years of follow-up. Mixed model regression analysis results showed a significant improvement in FA from baseline during the first 2 years of follow-up that stabilized by the third year of follow-up. These results demonstrate a long-term improvement in apparent white matter integrity following ischemic stroke that continues, at least, into the second year following the insult.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16310892</pmid><doi>10.1016/j.neurobiolaging.2005.10.008</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 2006-12, Vol.27 (12), p.1827-1833 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68984262 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Aged, 80 and over Brain Ischemia - epidemiology Brain Ischemia - pathology Cerebral ischemia Diffusion Magnetic Resonance Imaging - methods DTI Female Follow-Up Studies Humans Longitudinal Studies Longitudinal survey Male Middle Aged MRI Nerve Fibers, Myelinated - pathology Prospective Studies Time Factors |
| title | Longitudinal changes in white matter following ischemic stroke: A three-year follow-up study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T01%3A47%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Longitudinal%20changes%20in%20white%20matter%20following%20ischemic%20stroke:%20A%20three-year%20follow-up%20study&rft.jtitle=Neurobiology%20of%20aging&rft.au=Wang,%20Changsheng&rft.date=2006-12-01&rft.volume=27&rft.issue=12&rft.spage=1827&rft.epage=1833&rft.pages=1827-1833&rft.issn=0197-4580&rft.eissn=1558-1497&rft_id=info:doi/10.1016/j.neurobiolaging.2005.10.008&rft_dat=%3Cproquest_cross%3E68984262%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68984262&rft_id=info:pmid/16310892&rft_els_id=S0197458005003386&rfr_iscdi=true |