Longitudinal changes in white matter following ischemic stroke: A three-year follow-up study
Information on longitudinal changes in white matter after stroke is limited. The aim of the present study was to quantitatively investigate longitudinal changes in the microstructural integrity of non-lesioned white matter at 1–3 years following ischemic stroke. In a sample of 80 ischemic stroke pat...
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Veröffentlicht in: | Neurobiology of aging 2006-12, Vol.27 (12), p.1827-1833 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Information on longitudinal changes in white matter after stroke is limited. The aim of the present study was to quantitatively investigate longitudinal changes in the microstructural integrity of non-lesioned white matter at 1–3 years following ischemic stroke. In a sample of 80 ischemic stroke patients, we obtained diffusion tensor imaging (DTI) measures of fractional anisotropy (FA), an apparent measure of white matter integrity, in radiologically normal-appearing white matter at baseline and 3 years of follow-up. Mixed model regression analysis results showed a significant improvement in FA from baseline during the first 2 years of follow-up that stabilized by the third year of follow-up. These results demonstrate a long-term improvement in apparent white matter integrity following ischemic stroke that continues, at least, into the second year following the insult. |
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ISSN: | 0197-4580 1558-1497 |
DOI: | 10.1016/j.neurobiolaging.2005.10.008 |