Focal liver lesions in multiple myeloma: ecography, computed tomography, and magnetic resonance findings. A case report

According to autopsy data, diffuse hepatic infiltration occurs in up to 50% of cases with multiple myeloma. However, focal infiltration (single or multiple), although exceptional, is also possible. Therefore, multiple myeloma should be included in the extensive differential diagnosis of space-occupying liver lesions. We present the case of a 71-year-old man diagnosed with multiple myeloma with multiple focal lesions in the liver and spleen studied by different imaging techniques (ultrasound, multi-phase computed tomography and magnetic resonance). The definitive diagnosis was made by immunohistochemical analysis of material obtained by US-guided fine needle aspiration. We review the imaging findings reported in the literature for focal liver lesions in multiple myeloma and in extramedullary plasmacytoma of the liver.