Investigation into the factors affecting accuracy of mass measurements on a time-of-flight mass spectrometer using Design of Experiment
The results of an investigation of the parameters which have the most significant effect on the accuracy of mass measurements on a quadrupole orthogonal acceleration time‐of‐flight mass spectrometer (q‐oaToF) are reported. The influence of eight factors is investigated: ion abundances of reference a...
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| Veröffentlicht in: | Rapid communications in mass spectrometry 2007-01, Vol.21 (4), p.529-535 |
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| container_title | Rapid communications in mass spectrometry |
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| creator | Laures, Alice M.-F. Wolff, Jean-Claude Eckers, Christine Borman, Phil J. Chatfield, Marion J. |
| description | The results of an investigation of the parameters which have the most significant effect on the accuracy of mass measurements on a quadrupole orthogonal acceleration time‐of‐flight mass spectrometer (q‐oaToF) are reported. The influence of eight factors is investigated: ion abundances of reference and analyte compounds, mass difference between analyte and reference compounds, quality of calibration, number of reference acquisitions averaged and TDC (time‐to‐digital converter) settings (resolution, Np multiplier (number of pushes correction factor), minimum number of points, i.e. minimum acquisition width which defines a peak). To extract the maximum information from as few experiments as possible, a Design of Experiment approach was used. The data will be used as a basis for developing guidance on accurate mass measurement on q‐oaToF instruments. Copyright © 2007 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/rcm.2852 |
| format | Article |
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Mass Spectrom</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>21</volume><issue>4</issue><spage>529</spage><epage>535</epage><pages>529-535</pages><issn>0951-4198</issn><eissn>1097-0231</eissn><abstract>The results of an investigation of the parameters which have the most significant effect on the accuracy of mass measurements on a quadrupole orthogonal acceleration time‐of‐flight mass spectrometer (q‐oaToF) are reported. The influence of eight factors is investigated: ion abundances of reference and analyte compounds, mass difference between analyte and reference compounds, quality of calibration, number of reference acquisitions averaged and TDC (time‐to‐digital converter) settings (resolution, Np multiplier (number of pushes correction factor), minimum number of points, i.e. minimum acquisition width which defines a peak). To extract the maximum information from as few experiments as possible, a Design of Experiment approach was used. 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| ispartof | Rapid communications in mass spectrometry, 2007-01, Vol.21 (4), p.529-535 |
| issn | 0951-4198 1097-0231 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Histamine H2 Antagonists - chemistry Ranitidine - chemistry Reproducibility of Results Research Design Spectrometry, Mass, Electrospray Ionization - methods |
| title | Investigation into the factors affecting accuracy of mass measurements on a time-of-flight mass spectrometer using Design of Experiment |
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