Role of Macrophage Metalloelastase in Gut Inflammation

: Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP‐3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP‐12 in these idiopathic...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2006-08, Vol.1072 (1), p.386-388
Hauptverfasser:	PENDER, SYLVIA L.F., LI, C.K.F., SABATINO, A.D.I., MACDONALD, T.T., BUCKLEY, M.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Colitis, Ulcerative - enzymology Colitis, Ulcerative - physiopathology Crohn Disease - enzymology Crohn Disease - physiopathology Humans immune response inflammatory bowel diseases Inflammatory Bowel Diseases - enzymology Inflammatory Bowel Diseases - physiopathology intestine macrophages matrix metalloproteinase Matrix Metalloproteinase 12 Metalloendopeptidases - physiology tissue inflammation
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Beschreibung
Zusammenfassung:	: Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP‐3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP‐12 in these idiopathic diseases.
ISSN:	0077-8923 1749-6632
DOI:	10.1196/annals.1326.019