The Metabolic Sensor GCN2 Branches out

The Metabolic Sensor GCN2 Branches out

GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response...

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Veröffentlicht in:Cell metabolism 2007-02, Vol.5 (2), p.85-87
1. Verfasser: Towle, Howard C.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Humans
Leucine - deficiency
Lipid Metabolism
Liver - enzymology
Liver - metabolism
Mice
Protein-Serine-Threonine Kinases - deficiency
Protein-Serine-Threonine Kinases - metabolism
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Zusammenfassung:GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid deprivation.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2007.01.010