New Unstable Bladder Model in Hypercholesterolemia Rats

Abstract Objectives To evaluate the voiding function of the new vasculogenic erectile dysfunction (ED) model in hypercholesterolemic rats. Methods We used 14 adult 12-week-old male Sprague-Dawley rats. The cholesterol group received a 1% cholesterol diet for 8 weeks. During the initial 2 weeks, they also drank water containing 3 mg/mL of NG-nitro- l -arginine methyl ester. After 8 weeks, we performed cystometrography, a detrusor strip contraction study, and pathologic examination of the detrusor to confirm voiding dysfunction. The results of the cholesterol and control groups were compared. Results Compared with the control group values, the mean serum cholesterol and body weight were significantly elevated in the cholesterol group. The cholesterol group had shorter voiding intervals (377.6 ± 205.4 versus 121.8 ± 79.6 seconds, P