O-Acetylation in the O-specific polysaccharide isolated from Shigella flexneri serotype 2a

Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequ...

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Veröffentlicht in:	Carbohydrate research 2007-02, Vol.342 (3), p.643-647
Hauptverfasser:	Kubler-Kielb, Joanna, Vinogradov, Evgeny, Chu, Chiayung, Schneerson, Rachel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Carbohydrate Sequence Flexneri Glycosylation LPS Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular O Antigens - chemistry O-Acetylation O-Specific chain Shigella Shigella flexneri - chemistry
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Zusammenfassung:	Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequently for the immunogenicity of the polysaccharide-based vaccines against shigellosis. Here, we report the degree of O-acetylation and the localisation of O-acetyl groups and side-chain glucose substitution in the O-SP (scheme) in different preparations of S. flexneri type 2a LPS. [Display omitted]
ISSN:	0008-6215 1873-426X
DOI:	10.1016/j.carres.2006.09.017