Trisubstituted Aziridine Ring-Opening by Phenol Derivatives:  Stereo- and Regioselective Formation of Chiral Tertiary Alkyl-Aryl Ethers

Trisubstituted Aziridine Ring-Opening by Phenol Derivatives:  Stereo- and Regioselective Formation of Chiral Tertiary Alkyl-Aryl Ethers

An unprecedented stereo- and regioselective trisubstituted aziridine ring-opening by phenol derivatives was discovered. The reaction features very mild reaction conditions and broad functional group compatibility, which provides a good method for the stereoselective formation of tertiary alkyl-aryl...

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Veröffentlicht in:Organic letters 2006-10, Vol.8 (22), p.5105-5107
Hauptverfasser: Li, Pixu, Forbeck, Erin M, Evans, Cory D, Joullié, Madeleine M
Format: Artikel
Sprache:eng
Schlagworte:
Aziridines - chemistry
Catalysis
Ethers - chemical synthesis
Molecular Structure
Phenols - chemistry
Stereoisomerism
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Zusammenfassung:An unprecedented stereo- and regioselective trisubstituted aziridine ring-opening by phenol derivatives was discovered. The reaction features very mild reaction conditions and broad functional group compatibility, which provides a good method for the stereoselective formation of tertiary alkyl-aryl ethers in highly functionalized systems.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol062010w