Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep

This prospective, randomized, controlled experimental study looks at the effects on global and regional microvascular blood flow (RMBF) in an ovine model of septic shock after severe smoke inhalation injury. Sixteen sheep were randomized into two groups, a control group (no injury, n = 8) and a smok...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2006-11, Vol.26 (5), p.489-495
Hauptverfasser:	MAYBAUER, Dirk M, MAYBAUER, Marc O, TRABER, Lillian D, WESTPHAL, Martin, NAKANO, Yoshimitsu Y, ENKHBAATAR, Perenlei, MORITA, Naoki, HERNDON, David N, TRABER, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blood Pressure Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Disease Models, Animal Emergency and intensive care: infection, septic shock Female Heart Rate Intensive care medicine Lung - physiopathology Medical sciences Microcirculation Multiple Organ Failure - blood Multiple Organ Failure - physiopathology Nitrates - blood Nitrites - blood Respiratory Distress Syndrome, Adult - blood Respiratory Distress Syndrome, Adult - physiopathology Sheep, Domestic Shock, Septic - blood Shock, Septic - physiopathology Smoke Inhalation Injury - blood Smoke Inhalation Injury - mortality Smoke Inhalation Injury - physiopathology Survival Rate Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Beschreibung
Zusammenfassung:	This prospective, randomized, controlled experimental study looks at the effects on global and regional microvascular blood flow (RMBF) in an ovine model of septic shock after severe smoke inhalation injury. Sixteen sheep were randomized into two groups, a control group (no injury, n = 8) and a smoke/sepsis (SS) group (n = 8), which received an insufflation of 4 sets of 12 breaths of cotton smoke (
ISSN:	1073-2322 1540-0514
DOI:	10.1097/01.shk.0000230300.78515.ed