Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-δ
Obesity is one major cardiovascular risk factor. We tested effects of endurance exercise on cannabinoid receptor type 1 (CB1) and peroxisome proliferator-activated receptor-δ (PPAR-δ)-dependent pathways in adipose tissue. Male Wistar rats were randomly assigned to standard laboratory chow or a high-...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2007-03, Vol.354 (2), p.427-433 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Yan, Zhen Cheng Liu, Dao Yan Zhang, Li Li Shen, Chen Yi Ma, Qun Li Cao, Ting Bing Wang, Li Juan Nie, Hai Zidek, Walter Tepel, Martin Zhu, Zhi Ming |
| description | Obesity is one major cardiovascular risk factor. We tested effects of endurance exercise on cannabinoid receptor type 1 (CB1) and peroxisome proliferator-activated receptor-δ (PPAR-δ)-dependent pathways in adipose tissue. Male Wistar rats were randomly assigned to standard laboratory chow or a high-fat diet without and with regular endurance exercise. Exercise in rats on high-fat diet significantly reduced visceral fat mass, blood pressure, and adipocyte size (each p |
| doi_str_mv | 10.1016/j.bbrc.2006.12.213 |
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We tested effects of endurance exercise on cannabinoid receptor type 1 (CB1) and peroxisome proliferator-activated receptor-δ (PPAR-δ)-dependent pathways in adipose tissue. Male Wistar rats were randomly assigned to standard laboratory chow or a high-fat diet without and with regular endurance exercise. Exercise in rats on high-fat diet significantly reduced visceral fat mass, blood pressure, and adipocyte size (each p<0.05). Adipocyte hypertrophy induced by high-fat diet was accompanied by increased CB1 expression in adipose tissue, whereas exercise significantly reduced CB1 expression (each p<0.05). CB1 receptor expression and adipocyte differentiation were directly regulated by PPAR-δ. Adipocyte hypertrophy induced by high-fat diet was accompanied by reduced PPAR-δ. Furthermore, selective silencing of PPAR-δ by RNA interference in 3T3-L1-preadipocyte cells significantly increased CB1 expression from 1.00±0.06 (n=3) to 1.91±0.06 (n=3; p<0.01) and increased adipocyte differentiation, whereas adenovirus-mediated overexpression of PPAR-δ significantly reduced CB1 expression to 0.39±0.03 (n=3; p<0.01) and reduced adipocyte differentiation. In the presence of the CB1 antagonist rimonabant adipocyte differentiation in stimulated 3T3 L1 preadipocyte cells was significantly reduced. The study indicates that high-fat diet-induced hypertrophy of adipocytes is associated with increased CB1 receptor expression which is directly regulated by PPAR-δ. Both CB1 and PPAR-δ are intimately involved in therapeutic interventions against a most important cardiovascular risk factor.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2006.12.213</identifier><identifier>PMID: 17223076</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3T3 Cells ; Adipose Tissue - metabolism ; Animals ; Cannabinoid receptor type 1 ; Disease Models, Animal ; Exercise ; Male ; Metabolic Syndrome - metabolism ; Mice ; Obesity ; Obesity - metabolism ; Peroxisome proliferator-activated receptor-δ ; Physical Conditioning, Animal - physiology ; PPAR delta - physiology ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1 - metabolism ; Receptor, Cannabinoid, CB1 - physiology ; Visceral adipose tissue</subject><ispartof>Biochemical and biophysical research communications, 2007-03, Vol.354 (2), p.427-433</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-2343d7d4de754cb1661b6ca1bd99e6644120df5b019c18a8fc8321eb2bc094943</citedby><cites>FETCH-LOGICAL-c385t-2343d7d4de754cb1661b6ca1bd99e6644120df5b019c18a8fc8321eb2bc094943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2006.12.213$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17223076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Zhen Cheng</creatorcontrib><creatorcontrib>Liu, Dao Yan</creatorcontrib><creatorcontrib>Zhang, Li Li</creatorcontrib><creatorcontrib>Shen, Chen Yi</creatorcontrib><creatorcontrib>Ma, Qun Li</creatorcontrib><creatorcontrib>Cao, Ting Bing</creatorcontrib><creatorcontrib>Wang, Li Juan</creatorcontrib><creatorcontrib>Nie, Hai</creatorcontrib><creatorcontrib>Zidek, Walter</creatorcontrib><creatorcontrib>Tepel, Martin</creatorcontrib><creatorcontrib>Zhu, Zhi Ming</creatorcontrib><title>Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-δ</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Obesity is one major cardiovascular risk factor. We tested effects of endurance exercise on cannabinoid receptor type 1 (CB1) and peroxisome proliferator-activated receptor-δ (PPAR-δ)-dependent pathways in adipose tissue. Male Wistar rats were randomly assigned to standard laboratory chow or a high-fat diet without and with regular endurance exercise. Exercise in rats on high-fat diet significantly reduced visceral fat mass, blood pressure, and adipocyte size (each p<0.05). Adipocyte hypertrophy induced by high-fat diet was accompanied by increased CB1 expression in adipose tissue, whereas exercise significantly reduced CB1 expression (each p<0.05). CB1 receptor expression and adipocyte differentiation were directly regulated by PPAR-δ. Adipocyte hypertrophy induced by high-fat diet was accompanied by reduced PPAR-δ. Furthermore, selective silencing of PPAR-δ by RNA interference in 3T3-L1-preadipocyte cells significantly increased CB1 expression from 1.00±0.06 (n=3) to 1.91±0.06 (n=3; p<0.01) and increased adipocyte differentiation, whereas adenovirus-mediated overexpression of PPAR-δ significantly reduced CB1 expression to 0.39±0.03 (n=3; p<0.01) and reduced adipocyte differentiation. In the presence of the CB1 antagonist rimonabant adipocyte differentiation in stimulated 3T3 L1 preadipocyte cells was significantly reduced. The study indicates that high-fat diet-induced hypertrophy of adipocytes is associated with increased CB1 receptor expression which is directly regulated by PPAR-δ. Both CB1 and PPAR-δ are intimately involved in therapeutic interventions against a most important cardiovascular risk factor.</description><subject>3T3 Cells</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Cannabinoid receptor type 1</subject><subject>Disease Models, Animal</subject><subject>Exercise</subject><subject>Male</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Mice</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Peroxisome proliferator-activated receptor-δ</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>PPAR delta - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Cannabinoid, CB1 - metabolism</subject><subject>Receptor, Cannabinoid, CB1 - physiology</subject><subject>Visceral adipose tissue</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokPhBVggr9gl-DoeJ5bYoKr8SJXYFImd5Z8b6lEmDnYy7ax5JZ6jz4SHGcSuXV1d3e8cXZ1DyGtgNTCQ7za1tcnVnDFZA685NE_ICphiFQcmnpIVK5eKK_h-Rl7kvGEMQEj1nJxBy3nDWrkivy7vMLmQkSb0i8NMjQ9TLPsccl6Q7oKhzoyjsWGMwRfM4TTHROf9hBTo7U1wNzTkcvixDGZGT-2eTpjiXchxi3RKcQg9JlNElXFz2P2F_vlU979fkme9GTK-Os1z8u3j5fXF5-rq66cvFx-uKtd067nijWh864XHdi2cBSnBSmfAeqVQSiGAM9-vLQPloDNd77qGA1puHVNCieacvD36lpd-LphnvQ3Z4TCYEeOSteyUbNdSPgqCajtZoiwgP4IuxZwT9npKYWvSXgPTh470Rh860oeONHBdOiqiNyf3xW7R_5ecSinA-yOAJYxdwKSzCzg69KGkNmsfw0P-fwAAA6Xt</recordid><startdate>20070309</startdate><enddate>20070309</enddate><creator>Yan, Zhen Cheng</creator><creator>Liu, Dao Yan</creator><creator>Zhang, Li Li</creator><creator>Shen, Chen Yi</creator><creator>Ma, Qun Li</creator><creator>Cao, Ting Bing</creator><creator>Wang, Li Juan</creator><creator>Nie, Hai</creator><creator>Zidek, Walter</creator><creator>Tepel, Martin</creator><creator>Zhu, Zhi Ming</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070309</creationdate><title>Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-δ</title><author>Yan, Zhen Cheng ; Liu, Dao Yan ; Zhang, Li Li ; Shen, Chen Yi ; Ma, Qun Li ; Cao, Ting Bing ; Wang, Li Juan ; Nie, Hai ; Zidek, Walter ; Tepel, Martin ; Zhu, Zhi Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-2343d7d4de754cb1661b6ca1bd99e6644120df5b019c18a8fc8321eb2bc094943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>3T3 Cells</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Cannabinoid receptor type 1</topic><topic>Disease Models, Animal</topic><topic>Exercise</topic><topic>Male</topic><topic>Metabolic Syndrome - metabolism</topic><topic>Mice</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Peroxisome proliferator-activated receptor-δ</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>PPAR delta - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Cannabinoid, CB1 - metabolism</topic><topic>Receptor, Cannabinoid, CB1 - physiology</topic><topic>Visceral adipose tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Zhen Cheng</creatorcontrib><creatorcontrib>Liu, Dao Yan</creatorcontrib><creatorcontrib>Zhang, Li Li</creatorcontrib><creatorcontrib>Shen, Chen Yi</creatorcontrib><creatorcontrib>Ma, Qun Li</creatorcontrib><creatorcontrib>Cao, Ting Bing</creatorcontrib><creatorcontrib>Wang, Li Juan</creatorcontrib><creatorcontrib>Nie, Hai</creatorcontrib><creatorcontrib>Zidek, Walter</creatorcontrib><creatorcontrib>Tepel, Martin</creatorcontrib><creatorcontrib>Zhu, Zhi Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Zhen Cheng</au><au>Liu, Dao Yan</au><au>Zhang, Li Li</au><au>Shen, Chen Yi</au><au>Ma, Qun Li</au><au>Cao, Ting Bing</au><au>Wang, Li Juan</au><au>Nie, Hai</au><au>Zidek, Walter</au><au>Tepel, Martin</au><au>Zhu, Zhi Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-δ</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2007-03-09</date><risdate>2007</risdate><volume>354</volume><issue>2</issue><spage>427</spage><epage>433</epage><pages>427-433</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Obesity is one major cardiovascular risk factor. We tested effects of endurance exercise on cannabinoid receptor type 1 (CB1) and peroxisome proliferator-activated receptor-δ (PPAR-δ)-dependent pathways in adipose tissue. Male Wistar rats were randomly assigned to standard laboratory chow or a high-fat diet without and with regular endurance exercise. Exercise in rats on high-fat diet significantly reduced visceral fat mass, blood pressure, and adipocyte size (each p<0.05). Adipocyte hypertrophy induced by high-fat diet was accompanied by increased CB1 expression in adipose tissue, whereas exercise significantly reduced CB1 expression (each p<0.05). CB1 receptor expression and adipocyte differentiation were directly regulated by PPAR-δ. Adipocyte hypertrophy induced by high-fat diet was accompanied by reduced PPAR-δ. Furthermore, selective silencing of PPAR-δ by RNA interference in 3T3-L1-preadipocyte cells significantly increased CB1 expression from 1.00±0.06 (n=3) to 1.91±0.06 (n=3; p<0.01) and increased adipocyte differentiation, whereas adenovirus-mediated overexpression of PPAR-δ significantly reduced CB1 expression to 0.39±0.03 (n=3; p<0.01) and reduced adipocyte differentiation. In the presence of the CB1 antagonist rimonabant adipocyte differentiation in stimulated 3T3 L1 preadipocyte cells was significantly reduced. The study indicates that high-fat diet-induced hypertrophy of adipocytes is associated with increased CB1 receptor expression which is directly regulated by PPAR-δ. Both CB1 and PPAR-δ are intimately involved in therapeutic interventions against a most important cardiovascular risk factor.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17223076</pmid><doi>10.1016/j.bbrc.2006.12.213</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2007-03, Vol.354 (2), p.427-433 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 3T3 Cells Adipose Tissue - metabolism Animals Cannabinoid receptor type 1 Disease Models, Animal Exercise Male Metabolic Syndrome - metabolism Mice Obesity Obesity - metabolism Peroxisome proliferator-activated receptor-δ Physical Conditioning, Animal - physiology PPAR delta - physiology Rats Rats, Wistar Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB1 - physiology Visceral adipose tissue |
| title | Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-δ |
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