Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-δ

Obesity is one major cardiovascular risk factor. We tested effects of endurance exercise on cannabinoid receptor type 1 (CB1) and peroxisome proliferator-activated receptor-δ (PPAR-δ)-dependent pathways in adipose tissue. Male Wistar rats were randomly assigned to standard laboratory chow or a high-...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-03, Vol.354 (2), p.427-433
Hauptverfasser:	Yan, Zhen Cheng, Liu, Dao Yan, Zhang, Li Li, Shen, Chen Yi, Ma, Qun Li, Cao, Ting Bing, Wang, Li Juan, Nie, Hai, Zidek, Walter, Tepel, Martin, Zhu, Zhi Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adipose Tissue - metabolism Animals Cannabinoid receptor type 1 Disease Models, Animal Exercise Male Metabolic Syndrome - metabolism Mice Obesity Obesity - metabolism Peroxisome proliferator-activated receptor-δ Physical Conditioning, Animal - physiology PPAR delta - physiology Rats Rats, Wistar Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB1 - physiology Visceral adipose tissue
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Zusammenfassung:	Obesity is one major cardiovascular risk factor. We tested effects of endurance exercise on cannabinoid receptor type 1 (CB1) and peroxisome proliferator-activated receptor-δ (PPAR-δ)-dependent pathways in adipose tissue. Male Wistar rats were randomly assigned to standard laboratory chow or a high-fat diet without and with regular endurance exercise. Exercise in rats on high-fat diet significantly reduced visceral fat mass, blood pressure, and adipocyte size (each p
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2006.12.213