Predictors and relationships of serum 25 hydroxyvitamin D concentration with bone turnover markers, bone mineral density, and vitamin D receptor genotype in Emirati women

To determine factors influencing serum 25 hydroxyvitamin D (25OHD) concentration and relationships between serum 25OHD concentration, bone turnover markers, bone mineral density (BMD), and vitamin D receptor (VDR) genotype in Emirati women. Serum 25OHD, parathyroid hormone (PTH), osteocalcin (OC), v...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2006-11, Vol.39 (5), p.1136-1143
Hauptverfasser:	Saadi, Hussein F., Nagelkerke, Nicolaas, Benedict, Sheela, Qazaq, Hussein S., Zilahi, Erica, Mohamadiyeh, Mohammad K., Al-Suhaili, Abdulrahim I.
Format:	Artikel
Sprache:	eng
Schlagworte:	25 hydroxyvitamin D Adult Alleles Amino Acids - urine Analysis of Variance Biological and medical sciences Bone and Bones - metabolism Bone Density - physiology Bone mineral density Bone turnover markers Emirati women Female Fundamental and applied biological sciences. Psychology Gene Frequency Genotype Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Middle Aged Osteoarticular system. Muscles Osteocalcin - blood Parathyroid Hormone - blood Predictive Value of Tests Radiodiagnosis. Nmr imagery. Nmr spectrometry Receptors, Calcitriol - genetics Seasons Skeleton and joints United Arab Emirates Vertebrates: osteoarticular system, musculoskeletal system Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - diagnosis Vitamin D Deficiency - genetics Vitamin D receptor genotype Vitamin D-Binding Protein - blood
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Zusammenfassung:	To determine factors influencing serum 25 hydroxyvitamin D (25OHD) concentration and relationships between serum 25OHD concentration, bone turnover markers, bone mineral density (BMD), and vitamin D receptor (VDR) genotype in Emirati women. Serum 25OHD, parathyroid hormone (PTH), osteocalcin (OC), vitamin D binding protein (VDBP), and urinary deoxypyrdinoline (UDPD) concentrations and VDR genotype were determined in Emirati women volunteers who were participating in a study aiming at establishing a reference database for BMD. Serum 25OHD concentration in the 259 women volunteers was 25.3 ± 10.8 nmol/l (mean ± SD), and all had vitamin D deficiency (25OHD
ISSN:	8756-3282 1873-2763
DOI:	10.1016/j.bone.2006.05.010