Highly enantioselective nitroaldol reaction catalyzed by new chiral copper complexes

Highly enantioselective nitroaldol reaction catalyzed by new chiral copper complexes

Remarkable generality in scope of DATs/Cu catalysts for enantioselective nitroaldol reaction is described; excellent levels of stereoinduction are recorded for a range of aldehydes (ee 81-99%, 17 examples) and the possibility to employ the present catalytic system as the key step for the preparation...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2007-01 (6), p.616-618
Hauptverfasser: Bandini, Marco, Piccinelli, Fabio, Tommasi, Simona, Umani-Ronchi, Achille, Ventrici, Caterina
Format: Artikel
Sprache:eng
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Zusammenfassung:Remarkable generality in scope of DATs/Cu catalysts for enantioselective nitroaldol reaction is described; excellent levels of stereoinduction are recorded for a range of aldehydes (ee 81-99%, 17 examples) and the possibility to employ the present catalytic system as the key step for the preparation of highly functionalized tetrahydro-isoquinolines is demonstrated.
ISSN:1359-7345
1364-548X
DOI:10.1039/b613019d