Diels-Alder Approach to Polysubstituted Biaryls: Rapid Entry to Tri- and Tetra-ortho-substituted Phosphorus-Containing Biaryls

Rapid construction: A Diels–Alder‐based approach to the synthesis of highly functionalized biaryls from readily available precursors is disclosed. The utility of these biaryl templates in palladium‐mediated couplings is explored along with subsequent reductions of the nitro and phosphine oxide moieties. Finally, initial application of a synthesized biaryl as a highly active ligand in palladium‐mediated coupling is carried out.