A Randomized Trial of Treatment Interruption before Optimized Antiretroviral Therapy for Persons with Drug-Resistant HIV: 48-Week Virologic Results of ACTG A5086

BackgroundThe role of structured treatment interruption (STI) before optimized antiretroviral therapy (ART) in patients with drug-resistant human immunodeficiency virus type 1 (HIV-1) is uncertain MethodsAIDS Clinical Trial Group protocol A5086 was a prospective trial of 41 patients with multiple dr...

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Veröffentlicht in:	The Journal of infectious diseases 2006-11, Vol.194 (9), p.1309-1318
Hauptverfasser:	Benson, Constance A., Vaida, Florin, Havlir, Diane V., Downey, Gerald F., Lederman, Michael M., Gulick, Roy M., Glesby, Marshall J., Wantman, Michael, Bixby, Christian J., Rinehart, Alex R., Snyder, Sally, Wang, Rui, Patel, Sheran
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - therapeutic use Antiretrovirals Antivirals Arts Biological and medical sciences Drug Administration Schedule Drug Resistance, Multiple, Viral Female Genetic mutation Genotypes HIV HIV 1 HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV/AIDS Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Phylogeny RNA Time Factors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Viruses
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Zusammenfassung:	BackgroundThe role of structured treatment interruption (STI) before optimized antiretroviral therapy (ART) in patients with drug-resistant human immunodeficiency virus type 1 (HIV-1) is uncertain MethodsAIDS Clinical Trial Group protocol A5086 was a prospective trial of 41 patients with multiple drug class–resistant HIV who were randomized to undergo a 16-week STI followed by optimized ART (STI) or immediate optimized ART (no STI). The primary end point was the proportion of subjects with HIV-1 RNA loads
ISSN:	0022-1899 1537-6613
DOI:	10.1086/508289