An Anticoagulant with Light-Triggered Antidote Activity
A light remedy to overdosing: Aptamers with an intramolecular “caged” antisense region remain active until they are irradiated. Upon irradiation, the antisense activity is released and the aptamer refolds into an inactive structure (see scheme).
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| Veröffentlicht in: | Angewandte Chemie International Edition 2006-10, Vol.45 (40), p.6748-6750 |
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| container_end_page | 6750 |
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| container_issue | 40 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 45 |
| creator | Heckel, Alexander Buff, Maximilian C. R. Raddatz, Marie-Sophie L. Müller, Jens Pötzsch, Bernd Mayer, Günter |
| description | A light remedy to overdosing: Aptamers with an intramolecular “caged” antisense region remain active until they are irradiated. Upon irradiation, the antisense activity is released and the aptamer refolds into an inactive structure (see scheme). |
| doi_str_mv | 10.1002/anie.200602346 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Anticoagulants - chemistry Anticoagulants - pharmacology Antidotes - chemistry Antidotes - pharmacology antisense agents aptamers Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - pharmacology blood clotting Blood Coagulation caged compounds DNA Humans Thrombin - antagonists & inhibitors Thrombin - metabolism |
| title | An Anticoagulant with Light-Triggered Antidote Activity |
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