An Anticoagulant with Light-Triggered Antidote Activity

An Anticoagulant with Light-Triggered Antidote Activity

A light remedy to overdosing: Aptamers with an intramolecular “caged” antisense region remain active until they are irradiated. Upon irradiation, the antisense activity is released and the aptamer refolds into an inactive structure (see scheme).

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2006-10, Vol.45 (40), p.6748-6750
Hauptverfasser: Heckel, Alexander, Buff, Maximilian C. R., Raddatz, Marie-Sophie L., Müller, Jens, Pötzsch, Bernd, Mayer, Günter
Format: Artikel
Sprache:eng
Schlagworte:
Anticoagulants - chemistry
Anticoagulants - pharmacology
Antidotes - chemistry
Antidotes - pharmacology
antisense agents
aptamers
Aptamers, Nucleotide - chemistry
Aptamers, Nucleotide - pharmacology
blood clotting
Blood Coagulation
caged compounds
DNA
Humans
Thrombin - antagonists & inhibitors
Thrombin - metabolism
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Beschreibung
Zusammenfassung:A light remedy to overdosing: Aptamers with an intramolecular “caged” antisense region remain active until they are irradiated. Upon irradiation, the antisense activity is released and the aptamer refolds into an inactive structure (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200602346