In Vivo Glucose Measurement by Surface-Enhanced Raman Spectroscopy

In Vivo Glucose Measurement by Surface-Enhanced Raman Spectroscopy

This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used to obtain quantitative in vivo glucose measurements from an animal model. Silver film over nanosphere surfaces were functionalized with a two-component self-assembled monolayer, and subcutane...

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Veröffentlicht in:Analytical chemistry (Washington) 2006-10, Vol.78 (20), p.7211-7215
Hauptverfasser: Stuart, Douglas A, Yuen, Jonathan M, Shah, Nilam, Lyandres, Olga, Yonzon, Chanda R, Glucksberg, Matthew R, Walsh, Joseph T, Van Duyne, Richard P
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Animals
Chemistry
Electrochemistry
Exact sciences and technology
General, instrumentation
Glucose
Glucose - analysis
Glucose - chemistry
Nanotechnology
Rats
Rats, Sprague-Dawley
Rodents
Sensors
Silver
Spectrometric and optical methods
Spectrum analysis
Spectrum Analysis, Raman - instrumentation
Spectrum Analysis, Raman - methods
Surface Properties
Time Factors
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Zusammenfassung:This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used to obtain quantitative in vivo glucose measurements from an animal model. Silver film over nanosphere surfaces were functionalized with a two-component self-assembled monolayer, and subcutaneously implanted in a Sprague−Dawley rat such that the glucose concentration of the interstitial fluid could be measured by spectroscopically addressing the sensor through an optical window. The sensor had relatively low error (RMSEC = 7.46 mg/dL (0.41 mM) and RMSEP = 53.42 mg/dL (2.97 mM).
ISSN:0003-2700
1520-6882
DOI:10.1021/ac061238u