Differential suppression of menstrual fluid prostaglandin F2a, prostaglandin E2, 6-keto prostaglandin F1a and thromboxane B2 by suprofen in women with primary dysmenorrhea

Differential suppression of menstrual fluid prostaglandin F2a, prostaglandin E2, 6-keto prostaglandin F1a and thromboxane B2 by suprofen in women with primary dysmenorrhea

Eleven women with primary dysmenorrhea completed a randomized, double-blind, placebo-controlled, three-way cross-over study comparing 200 and 400mg suprofen. Menstrual fluid volume did not change. Mean+/-S.E.M. menstrual fluid PGF2a was significantly suppressed from 18.9+/-1.9 microg (placebo) to 10...

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Veröffentlicht in:Prostaglandins & other lipid mediators 2007-02, Vol.83 (1-2), p.146-153
Hauptverfasser: Dawood, M Yusoff, Khan-Dawood, Firyal S
Format: Artikel
Sprache:eng
Schlagworte:
6-Ketoprostaglandin F1 alpha - secretion
Adult
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Body Fluids - drug effects
Body Fluids - secretion
Dinoprost - secretion
Dinoprostone - secretion
Dysmenorrhea - drug therapy
Dysmenorrhea - physiopathology
Female
Humans
Menstruation - drug effects
Prostaglandins - secretion
Suprofen - pharmacology
Suprofen - therapeutic use
Thromboxane B2 - secretion
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Zusammenfassung:Eleven women with primary dysmenorrhea completed a randomized, double-blind, placebo-controlled, three-way cross-over study comparing 200 and 400mg suprofen. Menstrual fluid volume did not change. Mean+/-S.E.M. menstrual fluid PGF2a was significantly suppressed from 18.9+/-1.9 microg (placebo) to 10.9+/-1.7 and 9.3+/-2.1 microg with 200 and 400 mg suprofen, respectively (p=
ISSN:1098-8823
DOI:10.1016/j.prostaglandins.2006.10.009