Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone

Abstract Postoperative peritoneal adhesions cause pelvic pain, infertility, and potentially lethal bowel obstruction. We have designed and synthesized an injectable hydrogel composed of cross-linkable modified hyaluronic acids (HAs) conjugated to dexamethasone (HAX-DEX), and investigated its anti-in...

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Veröffentlicht in:	Biomaterials 2007-04, Vol.28 (10), p.1778-1786
Hauptverfasser:	Ito, Taichi, Fraser, Iain P, Yeo, Yoon, Highley, Christopher B, Bellas, Evangelia, Kohane, Daniel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Advanced Basic Science Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Cells, Cultured Cross-Linking Reagents - chemistry Cytokine Cytokines - immunology Dentistry Dexamethasone - administration & dosage Dexamethasone - chemistry Diffusion Drug Carriers - administration & dosage Drug Carriers - chemistry Drug release Hyaluronic Acid - administration & dosage Hyaluronic Acid - chemistry Hydrogel Hydrogels - administration & dosage Hydrogels - chemistry Inflammation Inflammation - drug therapy Inflammation - immunology Macrophages - drug effects Macrophages - immunology Male Materials Testing Mice Treatment Outcome
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Zusammenfassung:	Abstract Postoperative peritoneal adhesions cause pelvic pain, infertility, and potentially lethal bowel obstruction. We have designed and synthesized an injectable hydrogel composed of cross-linkable modified hyaluronic acids (HAs) conjugated to dexamethasone (HAX-DEX), and investigated its anti-inflammatory function. HAX-DEX formed a hydrogel in
ISSN:	0142-9612 1878-5905
DOI:	10.1016/j.biomaterials.2006.12.012