Seroprevalence of hepatitis C virus specific antibodies among Iraqi children with thalassaemia

The seroprevalence of hepatitis C virus (HCV) specific antibodies and HCV genotypes distribution were studied among 559 Iraqi children with thalassaemia in receipt of repeated blood transfusions. HCV-specific antibodies were detected in 376 (67.3%) serum samples using third-generation enzyme immunoa...

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Veröffentlicht in:	Eastern Mediterranean health journal 2006-01, Vol.12 (1-2), p.204-210
Hauptverfasser:	Al-Kubaisy, W A, Al-Naib, K T, Habib, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Donors Child Child Welfare - statistics & numerical data Child, Preschool Children Comorbidity Control Cross-Sectional Studies Donor Selection Genotype Health aspects Hepacivirus - genetics Hepatitis C - blood Hepatitis C - epidemiology Hepatitis C - etiology Hepatitis C - prevention & control Hepatitis C - virology Hepatitis C Antibodies - blood Hepatitis C virus Hospitals, Teaching Humans Immunoblotting Immunoenzyme Techniques Infection Control Iraq - epidemiology Population Surveillance Reverse Transcriptase Polymerase Chain Reaction Risk factors RNA, Viral - analysis RNA, Viral - genetics Seroepidemiologic Studies Thalassemia Thalassemia - complications Thalassemia - epidemiology Thalassemia - therapy Transfusion Reaction Urban Health - statistics & numerical data
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Zusammenfassung:	The seroprevalence of hepatitis C virus (HCV) specific antibodies and HCV genotypes distribution were studied among 559 Iraqi children with thalassaemia in receipt of repeated blood transfusions. HCV-specific antibodies were detected in 376 (67.3%) serum samples using third-generation enzyme immunoassay and confirmatory immunoblot assays. Of 78 randomly selected sera, 48 (61.5%) were HCV-RNA positive. HCV genotypes 1a, 1b, 4 and mixed 1b and 4 were demonstrated in 13 (27.1%), 11 (22.9%), 17 (35.4%) and 7 (14.6%) sera respectively. Strict measures for the controlling the spread of HCV are needed by introducing advanced techniques for blood donor screening.
ISSN:	1020-3397