In Vivo Molecular Probing of Cellular Compartments with Gold Nanoparticles and Nanoaggregates

Surface-enhanced Raman (SERS) signatures were measured from single living cells at different times after the uptake of gold nanoparticles. The spectra are indicative of chemical changes in the environment of the nanostructures over time. The increase of the SERS signal strength and parallel TEM stud...

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Veröffentlicht in:	Nano letters 2006-10, Vol.6 (10), p.2225-2231
Hauptverfasser:	Kneipp, Janina, Kneipp, Harald, McLaughlin, Margaret, Brown, Dennis, Kneipp, Katrin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cross-disciplinary physics: materials science rheology Endocytosis - physiology Exact sciences and technology Gold - chemistry Macrophages - cytology Macrophages - physiology Materials science Materials Testing Mice Molecular Probe Techniques Nanopowders Nanoscale materials and structures: fabrication and characterization Nanostructures - chemistry Nanostructures - ultrastructure Physics Spectrum Analysis, Raman - methods
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Beschreibung
Zusammenfassung:	Surface-enhanced Raman (SERS) signatures were measured from single living cells at different times after the uptake of gold nanoparticles. The spectra are indicative of chemical changes in the environment of the nanostructures over time. The increase of the SERS signal strength and parallel TEM studies indicate the formation of nanoaggregates providing optimum SERS enhancement for ultrasensitive probing inside the endosomal compartment. The results have implications for medical and biotechnology applications of SERS nanosensors in cells.
ISSN:	1530-6984 1530-6992
DOI:	10.1021/nl061517x