Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase

Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 nM of IC 50 inhibitory activity.

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2007-02, Vol.17 (3), p.841-845
Hauptverfasser: Ding, Yili, Smith, Kenneth L., Varaprasad, Chamakura V.N.S., Chang, Eugene, Alexander, John, Yao, Nanhua
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Sprache:eng
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