Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase

Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 nM of IC 50 inhibitory activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-02, Vol.17 (3), p.841-845
Hauptverfasser:	Ding, Yili, Smith, Kenneth L., Varaprasad, Chamakura V.N.S., Chang, Eugene, Alexander, John, Yao, Nanhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Biological and medical sciences Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology HCV Hepatitis C virus Indicators and Reagents Medical sciences NS5B ploymerase inhibitor Pharmacology. Drug treatments Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - pharmacology Synthesis Thiazoles - chemical synthesis Thiazoles - pharmacology Viral Nonstructural Proteins - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 nM of IC 50 inhibitory activity.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.08.104