Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis
Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistan...
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| Veröffentlicht in: | Neurology 2006-10, Vol.67 (7), p.1288-1290 |
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| container_title | Neurology |
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| creator | RINKER, John R TRINKAUS, Kathryn CROSS, Anne H |
| description | Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%). |
| doi_str_mv | 10.1212/01.wnl.0000238107.31364.21 |
| format | Article |
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We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/01.wnl.0000238107.31364.21</identifier><identifier>PMID: 17030770</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Biological and medical sciences ; Biomarkers - cerebrospinal fluid ; Cohort Studies ; Disability Evaluation ; Female ; Health Status Indicators ; Humans ; Immunoglobulin kappa-Chains - cerebrospinal fluid ; Immunomodulators ; Male ; Medical sciences ; Multiple Sclerosis - cerebrospinal fluid ; Multiple Sclerosis - diagnosis ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. 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We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).</description><subject>Biological and medical sciences</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Cohort Studies</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>Immunoglobulin kappa-Chains - cerebrospinal fluid</subject><subject>Immunomodulators</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Statistics as Topic</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhi3UChboX0AWUntL8NhJbHOrVlAqIXEoSJxqOc6YdevNpna2iH9fAyvtsXMZaeaZz5eQc2A1cOAXDOrnMdasGBcKmKwFiK6pORyQBbS8qzrBHz-QRcmrSiipjshxzr8YK0mpD8kRSCaYlGxBfl5F_GtnHOjyxzX1CZH-ttNkaQxPq5m6lQ1jpm6TEsaC0ecwr-gQsu1DDPMLndLmadzkkGkY6Xob5zBFpNlFTK_RU_LR25jx086fkIfrq_vlTXV79-378utt5bgWc9U2ChC4c9g7J9E7bEEPHlsppOC-7wFdj61wqvPKawdaDI0SqJlsuh6UOCFf3vuWff5sMc9mHbLDGO2Im202ndINV7L7Lwi6lY1mTQEv30FXDskJvZlSWNv0YoCZVxkMA1NkMHsZzJsMhkMpPttN2fZrHPalu78X4PMOsNnZ6JMdXch7ToHquGDiHzaakus</recordid><startdate>20061010</startdate><enddate>20061010</enddate><creator>RINKER, John R</creator><creator>TRINKAUS, Kathryn</creator><creator>CROSS, Anne H</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20061010</creationdate><title>Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis</title><author>RINKER, John R ; TRINKAUS, Kathryn ; CROSS, Anne H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-5481e12ccebcc7efce519dfe573732fbb1ecbe53c86f8f9c193d483e90746b183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers - cerebrospinal fluid</topic><topic>Cohort Studies</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Health Status Indicators</topic><topic>Humans</topic><topic>Immunoglobulin kappa-Chains - cerebrospinal fluid</topic><topic>Immunomodulators</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RINKER, John R</creatorcontrib><creatorcontrib>TRINKAUS, Kathryn</creatorcontrib><creatorcontrib>CROSS, Anne H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RINKER, John R</au><au>TRINKAUS, Kathryn</au><au>CROSS, Anne H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2006-10-10</date><risdate>2006</risdate><volume>67</volume><issue>7</issue><spage>1288</spage><epage>1290</epage><pages>1288-1290</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>17030770</pmid><doi>10.1212/01.wnl.0000238107.31364.21</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0028-3878 |
| ispartof | Neurology, 2006-10, Vol.67 (7), p.1288-1290 |
| issn | 0028-3878 1526-632X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Biological and medical sciences Biomarkers - cerebrospinal fluid Cohort Studies Disability Evaluation Female Health Status Indicators Humans Immunoglobulin kappa-Chains - cerebrospinal fluid Immunomodulators Male Medical sciences Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - diagnosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Pharmacology. Drug treatments Prognosis Reproducibility of Results Sensitivity and Specificity Statistics as Topic |
| title | Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis |
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