Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistan...

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Veröffentlicht in:	Neurology 2006-10, Vol.67 (7), p.1288-1290
Hauptverfasser:	RINKER, John R, TRINKAUS, Kathryn, CROSS, Anne H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers - cerebrospinal fluid Cohort Studies Disability Evaluation Female Health Status Indicators Humans Immunoglobulin kappa-Chains - cerebrospinal fluid Immunomodulators Male Medical sciences Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - diagnosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Pharmacology. Drug treatments Prognosis Reproducibility of Results Sensitivity and Specificity Statistics as Topic
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Zusammenfassung:	Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.wnl.0000238107.31364.21