Tin-Free and Catalytic Radical Cyclizations

Tin-Free and Catalytic Radical Cyclizations

H• transfer from CpCr(CO)3H to the kinetically favored double bond of a 1,6-diene can be used to initiate a radical cyclization. The CpCr(CO)3H can be regenerated by a hydrogen atmosphere, making the reaction catalytic as well as tin-free.

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Veröffentlicht in:Journal of the American Chemical Society 2007-01, Vol.129 (4), p.770-771
Hauptverfasser: Smith, Deborah M, Pulling, Mary E, Norton, Jack R
Format: Artikel
Sprache:eng
Schlagworte:
Biological Products - chemical synthesis
Catalysis
Cyclization
Tin - chemistry
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Zusammenfassung:H• transfer from CpCr(CO)3H to the kinetically favored double bond of a 1,6-diene can be used to initiate a radical cyclization. The CpCr(CO)3H can be regenerated by a hydrogen atmosphere, making the reaction catalytic as well as tin-free.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja0673276