Total Synthesis of (+)-Phyllantidine

Total Synthesis of (+)-Phyllantidine

Three into one will go! A three‐component coupling of a hydroxylamine, an aldehyde, and a cyclopropane diester provides the tetrahydro‐1,2‐oxazine scaffold necessary for completion of the first total synthesis of the natural product phyllantidine.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2006-10, Vol.45 (39), p.6560-6563
Hauptverfasser: Carson, Cheryl A., Kerr, Michael A.
Format: Artikel
Sprache:eng
Schlagworte:
alkaloids
cycloaddition
nitrone
oxazine
total synthesis
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Beschreibung
Zusammenfassung:Three into one will go! A three‐component coupling of a hydroxylamine, an aldehyde, and a cyclopropane diester provides the tetrahydro‐1,2‐oxazine scaffold necessary for completion of the first total synthesis of the natural product phyllantidine.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200602569