Independent prognostic significance of cell cycle regulator proteins p16 and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group

The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a serie...

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Veröffentlicht in:	British journal of cancer 2007-01, Vol.96 (2), p.306-313
Hauptverfasser:	Kommoss, S, du Bois, A, Ridder, R, Trunk, M J, Schmidt, D, Pfisterer, J, Kommoss, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Combined Modality Therapy Cyclin-Dependent Kinase Inhibitor p16 - physiology Female Humans Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Prognosis Prospective Studies Retinoblastoma Protein - physiology Survival Rate
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Zusammenfassung:	The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients with FIGO stage IIb-IV ovarian carcinoma which were enrolled in a randomized prospective trial evaluating two different platinum and paxlitaxel chemotherapy combinations after radical surgery. p16(INK4a) negative tumours (17/300; 6%) had a significantly worse prognosis (univariate analysis, P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6603531