Total Synthesis of Marinomycins A-C
Ocean's three: Unearthed from the bottom of the ocean off the coast of La Jolla (California, USA), marinomycins A–C, which differ in geometry about the C8C9 and C8′C9′ double bonds, have been prepared by total synthesis through a strategy that features a Suzuki coupling reaction to forge thei...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2006-10, Vol.45 (39), p.6527-6532 |
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| container_end_page | 6532 |
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| container_issue | 39 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 45 |
| creator | Nicolaou, K. C. Nold, Andrea L. Milburn, Robert R. Schindler, Corinna S. |
| description | Ocean's three: Unearthed from the bottom of the ocean off the coast of La Jolla (California, USA), marinomycins A–C, which differ in geometry about the C8C9 and C8′C9′ double bonds, have been prepared by total synthesis through a strategy that features a Suzuki coupling reaction to forge their remarkable polyunsaturated 44‐membered‐ring systems (see picture). |
| doi_str_mv | 10.1002/anie.200601867 |
| format | Article |
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| ispartof | Angewandte Chemie International Edition, 2006-10, Vol.45 (39), p.6527-6532 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Actinobacteria - chemistry Alkenes - chemical synthesis Anti-Bacterial Agents - chemical synthesis antibiotics Antibiotics, Antineoplastic - chemical synthesis antitumor agents Crystallography, X-Ray Indicators and Reagents Lactones - chemical synthesis Macrolides - chemical synthesis Magnetic Resonance Spectroscopy Models, Molecular natural products Photochemistry Stereoisomerism Suzuki coupling total synthesis |
| title | Total Synthesis of Marinomycins A-C |
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