Total Synthesis of Marinomycins A-C

Ocean's three: Unearthed from the bottom of the ocean off the coast of La Jolla (California, USA), marinomycins A–C, which differ in geometry about the C8C9 and C8′C9′ double bonds, have been prepared by total synthesis through a strategy that features a Suzuki coupling reaction to forge thei...

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Veröffentlicht in:	Angewandte Chemie International Edition 2006-10, Vol.45 (39), p.6527-6532
Hauptverfasser:	Nicolaou, K. C., Nold, Andrea L., Milburn, Robert R., Schindler, Corinna S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacteria - chemistry Alkenes - chemical synthesis Anti-Bacterial Agents - chemical synthesis antibiotics Antibiotics, Antineoplastic - chemical synthesis antitumor agents Crystallography, X-Ray Indicators and Reagents Lactones - chemical synthesis Macrolides - chemical synthesis Magnetic Resonance Spectroscopy Models, Molecular natural products Photochemistry Stereoisomerism Suzuki coupling total synthesis
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Beschreibung
Zusammenfassung:	Ocean's three: Unearthed from the bottom of the ocean off the coast of La Jolla (California, USA), marinomycins A–C, which differ in geometry about the C8C9 and C8′C9′ double bonds, have been prepared by total synthesis through a strategy that features a Suzuki coupling reaction to forge their remarkable polyunsaturated 44‐membered‐ring systems (see picture).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200601867