A protein kinase signal-responsive gene carrier modified RGD peptide

Development and evaluation of RGD peptide modified signal-responsive gene carrier are reported. We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into li...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-11, Vol.16 (22), p.5740-5743
Hauptverfasser:	Oishi, Jun, Ijuin, Moeko, Sonoda, Tatsuhiko, Kang, Jeong-Hun, Kawamura, Kenji, Mori, Takeshi, Niidome, Takuro, Katayama, Yoshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Cell Line, Tumor DNA - genetics DNA - metabolism Enzyme Activation Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene therapy Genetic Therapy - methods Health. Pharmaceutical industry HeLa Cells Humans Industrial applications and implications. Economical aspects Integrins - drug effects Integrins - genetics Integrins - metabolism Luciferases - genetics Luciferases - metabolism Oligopeptides - chemical synthesis Oligopeptides - pharmacology Protein kinase Protein Kinases - genetics Protein Kinases - metabolism RGD peptide Signal Transduction - drug effects
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Beschreibung
Zusammenfassung:	Development and evaluation of RGD peptide modified signal-responsive gene carrier are reported. We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.08.096