Mutations in BHD and TP53 genes, but not in HNF1beta gene, in a large series of sporadic chromophobe renal cell carcinoma

BHD, TP53, and HNF1beta on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1beta mutations, (84% mutations involved chromophobe), suggesting a role for...

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Veröffentlicht in:	British journal of cancer 2007-01, Vol.96 (2), p.336-340
Hauptverfasser:	Gad, S, Lefèvre, S H, Khoo, S K, Giraud, S, Vieillefond, A, Vasiliu, V, Ferlicot, S, Molinié, V, Denoux, Y, Thiounn, N, Chrétien, Y, Méjean, A, Zerbib, M, Benoît, G, Hervé, J M, Allègre, G, Bressac-de Paillerets, B, Teh, B T, Richard, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Renal Cell - genetics Genes, p53 Hepatocyte Nuclear Factor 1-beta - genetics Humans Kidney Neoplasms - genetics Mutation Polymorphism, Single Nucleotide Proteins - genetics Proto-Oncogene Proteins - genetics Tumor Suppressor Proteins - genetics
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Zusammenfassung:	BHD, TP53, and HNF1beta on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1beta mutations, (84% mutations involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype.
ISSN:	0007-0920