Synthesis of the ester side chains of some potently antileukemic harringtonia alkaloids from chiral citrates

Synthesis of the ester side chains of some potently antileukemic harringtonia alkaloids from chiral citrates

The selective reduction of one of the three carboxyl groups of two chiral citric acid derivatives to the corresponding aldehydes, under Rosenmund conditions, are reported together with the application of these aldehydes to the syntheses of the ester side chains of some potently antileukemic Cephalot...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2006-01 (30), p.3243-3245
Hauptverfasser: Ancliff, Rachael A, Russell, Andrew T, Sanderson, Adam J
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - chemistry
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Cephalotaxus - chemistry
Citrates - chemistry
Esters - chemical synthesis
Esters - chemistry
Molecular Structure
Oxidation-Reduction
Stereoisomerism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The selective reduction of one of the three carboxyl groups of two chiral citric acid derivatives to the corresponding aldehydes, under Rosenmund conditions, are reported together with the application of these aldehydes to the syntheses of the ester side chains of some potently antileukemic Cephalotaxus alkaloids e.g. anhydroharringtonine.
ISSN:1359-7345
1364-548X
DOI:10.1039/b605339d