Radical Trifluoromethylation of Ketone Silyl Enol Ethers by Activation with Dialkylzinc

Radical Trifluoromethylation of Ketone Silyl Enol Ethers by Activation with Dialkylzinc

The radical trifluoromethylation of ketone silyl enol ethers gave α-CF3 ketones in good yields with wide scope of the ketonic substrates including acyclic ketones and cyclopentanone. The use of dialkylzinc to activate the silyl enol ethers is the key to the efficient radical trifluoromethylation.

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Veröffentlicht in:Organic letters 2006-10, Vol.8 (21), p.4671-4673
Hauptverfasser: Mikami, Koichi, Tomita, Yuichi, Ichikawa, Yoshiyuki, Amikura, Kazutoshi, Itoh, Yoshimitsu
Format: Artikel
Sprache:eng
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Zusammenfassung:The radical trifluoromethylation of ketone silyl enol ethers gave α-CF3 ketones in good yields with wide scope of the ketonic substrates including acyclic ketones and cyclopentanone. The use of dialkylzinc to activate the silyl enol ethers is the key to the efficient radical trifluoromethylation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0611301