Long QT Syndrome in Adults

Long QT Syndrome in Adults Andrew J. Sauer, Arthur J. Moss, Scott McNitt, Derick R. Peterson, Wojciech Zareba, Jennifer L. Robinson, Ming Qi, Ilan Goldenberg, Jenny B. Hobbs, Michael J. Ackerman, Jesaia Benhorin, W. Jackson Hall, Elizabeth S. Kaufman, Emanuela H. Locati, Carlo Napolitano, MD, Silvia...

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Veröffentlicht in:	Journal of the American College of Cardiology 2007-01, Vol.49 (3), p.329-337
Hauptverfasser:	Sauer, Andrew J., BS, Moss, Arthur J., MD, McNitt, Scott, MS, Peterson, Derick R., PhD, Zareba, Wojciech, MD, PhD, Robinson, Jennifer L., MS, Qi, Ming, PhD, Goldenberg, Ilan, MD, Hobbs, Jenny B., BA, Ackerman, Michael J., MD, PhD, Benhorin, Jesaia, MD, Hall, W. Jackson, PhD, Kaufman, Elizabeth S., MD, Locati, Emanuela H., MD, PhD, Napolitano, Carlo, MD, Priori, Silvia G., MD, PhD, Schwartz, Peter J., MD, Towbin, Jeffrey A., MD, Vincent, G. Michael, MD, Zhang, Li, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenergic beta-Antagonists - therapeutic use Adult Age Age Distribution Biological and medical sciences Cardiac dysrhythmias Cardiology Cardiology. Vascular system Cardiovascular Child development Cohort Studies Confidence intervals Death, Sudden, Cardiac - epidemiology Drug therapy Electrocardiography Female Females Gender Genes Genetic Predisposition to Disease - epidemiology Genotype Genotype & phenotype Heart Heart attacks Heterozygote Humans Internal Medicine KCNQ1 Potassium Channel - genetics Long QT syndrome Long QT Syndrome - drug therapy Long QT Syndrome - genetics Long QT Syndrome - mortality Male Medical sciences Mutation Patients Population Potassium Proportional Hazards Models Ratios Risk Factors Severity of Illness Index Sex Distribution Statistics, Nonparametric Studies Survival Analysis
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Zusammenfassung:	Long QT Syndrome in Adults Andrew J. Sauer, Arthur J. Moss, Scott McNitt, Derick R. Peterson, Wojciech Zareba, Jennifer L. Robinson, Ming Qi, Ilan Goldenberg, Jenny B. Hobbs, Michael J. Ackerman, Jesaia Benhorin, W. Jackson Hall, Elizabeth S. Kaufman, Emanuela H. Locati, Carlo Napolitano, MD, Silvia G. Priori, Peter J. Schwartz, Jeffrey A. Towbin, G. Michael Vincent, Li Zhang The clinical course and risk factors for cardiac events in genotype-confirmed adult patients with long QT syndrome (LQTS) were investigated. The severity of LQTS in adulthood can be risk stratified with information regarding genotype, gender, corrected QT duration, and history of cardiac events. Beta-blockers effectively reduce but do not eliminate the risk of both syncopal and life-threatening cardiac events in adult patients with mutation-confirmed LQTS.
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2006.08.057